Transcription Factor

						

			
Accessions: 1ic8_B (3D-footprint 20231221)

			
Names: HEPATOCYTE NUCLEAR FACTOR 1-ALPHA, HNF-1-alpha, HNF-1A, HNF1A_HUMAN, LFB1, Liver-specific transcription factor LF-B1, TCF-1, Transcription factor 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P20823
Length: 173
Pfam Domains:      1-92 Hepatocyte nuclear factor 1 (HNF-1), N terminus
   96-168 Homeobox domain
Sequence: 
(in bold interface residues)		   1 ILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHL   60
  61 SQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHRNRFKWGPASQQILFQAYERQKNPS  120
 121 KEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFR
Interface Residues: 56, 57, 58, 59, 61, 62, 68, 69, 98, 158, 159, 160, 161, 164, 165, 168
3D-footprint Homologues: 2h8r_B, 1ic8_B, 4on0_B, 5zfz_A, 4j19_B, 1le8_A
Binding Motifs: 1ic8_AB GGTGArTTATtAACCAA
1ic8_B TTaATAnntcGCC
Binding Sites: 1ic8_E
1ic8_F
			
Publications: Chi Y.I, Frantz J.D, Oh B.C, Hansen L, Dhe-Paganon S, Shoelson S.E. Diabetes mutations delineate an atypical POU domain in HNF-1alpha. Molecular cell 10:1129-37 (2002). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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