Transcription Factor
| Accessions: | Q96NG8 (JASPAR 2024) |
| Names: | ZN582_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q96NG8 |
| Length: | 517 |
| Pfam Domains: | 8-46 KRAB box 188-210 Zinc-finger double domain 198-217 C2H2-type zinc finger 199-221 C2H2-type zinc finger 199-221 Zinc finger, C2H2 type 216-237 Zinc-finger double domain 226-249 C2H2-type zinc finger 227-249 C2H2-type zinc finger 227-249 Zinc finger, C2H2 type 244-266 Zinc-finger double domain 254-277 C2H2-type zinc finger 255-277 C2H2-type zinc finger 255-277 Zinc finger, C2H2 type 271-293 Zinc-finger double domain 283-305 Zinc finger, C2H2 type 283-305 C2H2-type zinc finger 283-296 C2H2-type zinc finger 297-322 Zinc-finger double domain 311-333 Zinc finger, C2H2 type 311-333 C2H2-type zinc finger 311-333 C2H2-type zinc finger 328-349 Zinc-finger double domain 338-359 C2H2-type zinc finger 339-361 Zinc finger, C2H2 type 339-361 C2H2-type zinc finger 354-376 Zinc-finger double domain 366-377 C2H2-type zinc finger 367-389 Zinc finger, C2H2 type 367-389 C2H2-type zinc finger 382-406 Zinc-finger double domain 395-417 Zinc finger, C2H2 type 395-417 C2H2-type zinc finger 395-406 C2H2-type zinc finger 409-434 Zinc-finger double domain 422-441 C2H2-type zinc finger 423-445 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MSLGSELFRDVAIVFSQEEWQWLAPAQRDLYRDVMLETYSNLVSLGLAVSKPDVISFLEQ 60 61 GKEPWMVERVVSGGLCPVLESRYDTKELFPKQHVYEVESPQWEIMESLTSYGLECSSFQD 120 121 DWECRNQFDRQQGNPDRHFHQMIIRHEEMPTFDQHASLTFYQKIHTREKPFGYNKCRKDF 180 181 WQKELLINHQGIYTNEKPYKCKECGKAFKYGSRLIQHENIHSGKKPYECKECGKAFNSGS 240 241 NFIQHQRVHTGEKPYECKDCEKAFSRSSQLIEHQRTHTGEKPYQCKECGKAFNRISHLKV 300 301 HYRIHTGEKPYACKECGKTFSHRSQLIQHQTVHTGRKLYECKECGKAFNQGSTLIRHQRI 360 361 HTGEKPYECKVCGKAFRVSSQLKQHQRIHTGEKPYQCKVCGRAFKRVSHLTVHYRIHTGE 420 421 KPYECKECGKAFSHCSQLIHHQVIHTEKKPYEYKECEKTLSHDSTTVQPQRMHNRETHVN 480 481 IINVEKPSISSYPLLIIREFMLASNHMNGSNGESPLA |
| Interface Residues: | 182, 184, 188, 209, 210, 213, 216, 220, 237, 238, 239, 240, 241, 243, 244, 246, 247, 248, 250, 265, 266, 267, 268, 269, 272, 293, 294, 295, 296, 297, 299, 300, 303, 322, 323, 324, 325, 327, 328, 332, 339, 349, 350, 351, 352, 353, 355, 356, 359, 360, 377, 378, 379, 380, 381, 382, 384, 385, 390, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 416, 433, 434, 435, 436, 437, 440, 462, 464, 465, 468 |
| 3D-footprint Homologues: | 7w1m_H, 8ssq_A, 8ssu_A, 1tf3_A, 6jnm_A, 5k5i_A, 6blw_A, 6u9q_A, 2gli_A, 5ei9_F, 2jpa_A, 7n5w_A, 5kl3_A, 5v3j_F, 2wbs_A, 1tf6_A, 8h9h_G, 5yel_A, 7txc_E, 5k5l_F, 6e94_A, 1ubd_C, 2kmk_A, 6ml4_A, 5kkq_D, 8gn3_A, 7ysf_A, 2lt7_A, 6a57_A, 3uk3_C, 8cuc_F, 7y3l_A, 4x9j_A, 1f2i_J, 1g2f_F, 4m9v_C, 7y3m_I, 1llm_D, 2drp_D, 5yj3_D |
| Binding Motifs: | MA1983.1 tcTgTTACTTGCAGCCaAAwg MA1983.2 tcTgTTACTTGCAGCCaAA |
| Binding Sites: | MA1983.1.1 MA1983.1.10 / MA1983.1.9 MA1983.1.10 / MA1983.1.11 MA1983.1.11 / MA1983.1.12 MA1983.1.12 / MA1983.1.13 MA1983.1.13 / MA1983.1.14 MA1983.1.14 / MA1983.1.15 MA1983.1.15 / MA1983.1.16 MA1983.1.17 MA1983.1.16 / MA1983.1.18 MA1983.1.17 / MA1983.1.19 MA1983.1.2 MA1983.1.18 / MA1983.1.20 MA1983.1.3 MA1983.1.4 MA1983.1.4 / MA1983.1.5 MA1983.1.5 / MA1983.1.6 MA1983.1.6 / MA1983.1.7 MA1983.1.7 / MA1983.1.8 MA1983.1.8 / MA1983.1.9 MA1983.1.19 MA1983.1.20 MA1983.2.1 MA1983.2.10 MA1983.2.11 MA1983.2.12 MA1983.2.13 MA1983.2.14 MA1983.2.15 MA1983.2.16 MA1983.2.17 MA1983.2.18 MA1983.2.19 MA1983.2.2 MA1983.2.20 MA1983.2.3 MA1983.2.4 MA1983.2.5 MA1983.2.6 MA1983.2.7 MA1983.2.8 MA1983.2.9 |
| Publications: | Li X, Qiu S, Shi J, Wang S, Wang M, Xu Y, Nie Z, Liu C, Liu C. A new function of copper zinc superoxide dismutase: as a regulatory DNA-binding protein in gene expression in response to intracellular hydrogen peroxide. Nucleic Acids Res 47:5074-5085 (2019). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.