Transcription Factor

						

			
Accessions: UP00088A (UniPROBE 20160601)

			
Names: Lot1, Plagl1, Pleiomorphic adenoma gene-like 1, Zac1
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: O35745
Description: Pleiomorphic adenoma gene-like 1: Mus musculus similar to zinc finger protein regulator of apoptosis and cell cycle arrest (Zac1), mRNA
Length: 221
Pfam Domains:      3-25 Zinc finger, C2H2 type
     3-26 C2H2-type zinc finger
     3-18 C2H2-type zinc finger
    19-44 Zinc-finger double domain
    31-55 Zinc finger, C2H2 type
    31-55 C2H2-type zinc finger
    48-71 Zinc-finger double domain
    60-71 C2H2-type zinc finger
    61-83 Zinc finger, C2H2 type
    61-83 C2H2-type zinc finger
   75-101 Zinc-finger double domain
   90-112 C2H2-type zinc finger
  119-141 C2H2-type zinc finger
  134-166 Zinc-finger double domain
  155-177 Zinc finger, C2H2 type
  155-177 C2H2-type zinc finger
  170-193 Zinc-finger double domain
  183-206 C2H2-type zinc finger
  185-206 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 APFRCQKCGKSFVTLEKFTIHNYSHSRERPFKCSKAECGKAFVSKYKLMRHMATHSPQKI   60
  61 HQCTHCEKTFNRKDHLKNHLQTHDPNKISYACDDCGKKYHTMLGYKRHLALHSASNGDLT  120
 121 CGVCTLELGSTEVLLDHLKSHAEEKANQAPREKKYQCDHCDRCFYTRKDVRRHLVVHTGC  180
 181 KDFLCQFCAQRFGRKDHLTRHTKKTHSQELMQENMQAGDYQ
Interface Residues: 3, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 26, 43, 44, 45, 46, 47, 48, 50, 51, 71, 72, 73, 74, 75, 77, 78, 100, 101, 102, 103, 104, 105, 106, 107, 108, 111, 113, 130, 131, 132, 133, 135, 136, 142, 164, 165, 166, 167, 168, 169, 171, 172, 176, 193, 194, 195, 196, 197, 198, 200
3D-footprint Homologues: 2kmk_A, 8cuc_F, 1tf3_A, 7y3l_A, 6jnm_A, 7eyi_G, 8ssu_A, 2gli_A, 6blw_A, 5kkq_D, 6u9q_A, 1ubd_C, 6wmi_A, 5ei9_F, 8ssq_A, 1mey_C, 7w1m_H, 5und_A, 4m9v_C, 2i13_A, 6a57_A, 2jpa_A, 7n5w_A, 3uk3_C, 1f2i_J, 5k5i_A, 1g2f_F, 1tf6_A, 4x9j_A, 7txc_E, 5kl3_A, 2wbs_A, 5yj3_D, 8h9h_G, 7ysf_A, 6ml4_A, 5v3j_F, 1llm_D, 5yel_A, 2lt7_A, 6e94_A, 2drp_D, 8gn3_A, 7y3m_I
Binding Motifs: UP00088A_1 kyggGGGssCCCckrs
UP00088A_2 rctgGGGGGTACccytw
Binding Sites: AAGGGGCC
AGGCCCCC
AGGCCCCT
AGGGCCCC
AGGGGCCC
AGGGGGCC
CGGCCCCC
CGGGCCCC
CGGGGGCC
CGGGGGGC
GAGGCCCC
GAGGGGCC
GCCCCCCA
GGCCCCCA
GGCCCCCC
GGGCCCCA
GGGCCCCC
GGGGCCCA
GGGGGCCA
GGGGGCAC
			
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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