Transcription Factor
| Accessions: | 5vmu_A (3D-footprint 20231221), 5vmw_A (3D-footprint 20231221), 5vmy_A (3D-footprint 20231221) |
| Names: | KAISO_HUMAN, Transcriptional regulator Kaiso, Zinc finger and BTB domain-containing protein 33 |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Length: | 121 |
| Pfam Domains: | 28-51 Zinc-finger double domain 42-64 C2H2-type zinc finger 58-80 Zinc-finger double domain 70-93 Zinc finger, C2H2 type 70-93 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 DDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKVFPLAEYRTKH 60 61 EIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSGDSKLYRLHPCRSLQIRQYAYL 120 121 S |
| Interface Residues: | 14, 24, 25, 26, 27, 28, 30, 31, 33, 34, 37, 52, 53, 54, 55, 56, 57, 58, 59, 60, 80, 81, 82, 83, 84, 85, 86, 87, 88, 91, 115, 117 |
| 3D-footprint Homologues: | 2kmk_A, 6jnm_A, 1tf3_A, 6ml4_A, 7n5w_A, 6wmi_A, 5ei9_F, 8ssq_A, 1mey_C, 7w1m_H, 5und_A, 2drp_D, 7eyi_G, 5k5i_A, 8ssu_A, 2gli_A, 1g2f_F, 6blw_A, 5kkq_D, 1tf6_A, 6u9q_A, 4x9j_A, 2i13_A, 6e94_A, 5kl3_A, 1ubd_C, 7ysf_A, 5v3j_F, 8h9h_G, 2lt7_A, 6a57_A, 8gn3_A, 2jpa_A, 3uk3_C, 8cuc_F, 7y3l_A, 1f2i_J, 5yel_A, 1llm_D, 7txc_E, 2wbs_A, 4m9v_C, 7y3m_I, 5yj3_D |
| Binding Motifs: | 5vmu_A tnnnnGga 5vmw_A TCCcGcGA 5vmy_A TCGCGGGA |
| Binding Sites: | 5vmw_D 5vmy_E 5vmw_E 5vmu_D / 5vmy_D 5vmu_E |
| Publications: | Nikolova EN, Stanfield RL, Dyson HJ, Wright PE. CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso. Biochemistry 57:2109-2120 (2018). [Pubmed] |
| Related annotations: | PaperBLAST |
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