DNA Binding Motif

						

			
Accessions: 5vmw_A (3D-footprint 20231221)

			
Names: Transcriptional regulator Kaiso
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Kaiso (ZBTB33) zinc finger DNA binding domain in complex with a double CpG-methylated DNA resembling the specific Kaiso binding sequence (KBS)
Length: 8
Consensus: TCCcGcGA
Weblogo: 
PSSM: P0      A      C      G      T
01     10      0      0     86      T
02      0     96      0      0      C
03      0     96      0      0      C
04     12     64     10     10      c
05      0      0     96      0      G
06     10     64     12     10      c
07      0     10     85      1      G
08     96      0      0      0      A
Binding TFs: 5vmw_A (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Binding Sites: 5vmw_D
5vmw_E
			
Publications: Nikolova EN, Stanfield RL, Dyson HJ, Wright PE. CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso. Biochemistry 57:2109-2120 (2018). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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