Transcription Factor
| Accessions: | ZNF597 (HT-SELEX2 May2017), Q96LX8 (JASPAR 2024) |
| Names: | ENSG00000167981, ZNF597, ZN597_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: KRAB_Znf_C2H2 experiment: HT-SELEX Hamming distance: 2 cycle: 4, TF family: KRAB_Znf_C2H2 experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 4 |
| Length: | 424 |
| Pfam Domains: | 16-51 KRAB box 155-169 C2H2-type zinc finger 156-178 Zinc finger, C2H2 type 156-178 C2H2-type zinc finger 171-195 Zinc-finger double domain 184-206 C2H2-type zinc finger 184-206 Zinc finger, C2H2 type 184-204 C2H2-type zinc finger 198-222 Zinc-finger double domain 211-234 C2H2-type zinc finger 212-234 C2H2-type zinc finger 212-234 Zinc finger, C2H2 type 226-249 Zinc-finger double domain 239-263 C2H2-type zinc finger 240-262 C2H2-type zinc finger 341-360 C2H2-type zinc finger 342-363 C2H2-type zinc finger 342-363 Zinc finger, C2H2 type 358-379 Zinc-finger double domain 368-378 C2H2-type zinc finger 384-408 Zinc-finger double domain 397-419 Zinc finger, C2H2 type 397-419 C2H2-type zinc finger 397-419 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPE 60 61 INQQLSLESMELDELALEKYPIAAPLVPYPEKSSEDGVGNPEAKILSGTPTYKRRVISLL 120 121 VTIENHTPLVELSEYLGTNTLSEILDSPWEGAKNVYKCPECDQNFSDHSYLVLHQKIHSG 180 181 EKKHKCGDCGKIFNHRANLRTHRRIHTGEKPYKCAKCSASFRQHSHLSRHMNSHVKEKPY 240 241 TCSICGRGFMWLPGLAQHQKSHSAENTYESTNCDKHFNEKPNLALPEETFVSGPQYQHTK 300 301 CMKSFRQSLYPALSEKSHDEDSERCSDDGDNFFSFSKFKPLQCPDCDMTFPCFSELISHQ 360 361 NIHTEERPHKCKTCEESFALDSELACHQKSHMLAEPFKCTVCGKTFKSNLHLITHKRTHI 420 421 KNTT |
| Interface Residues: | 166, 167, 168, 169, 170, 172, 173, 175, 176, 177, 179, 194, 195, 196, 197, 198, 199, 201, 202, 222, 223, 224, 225, 226, 227, 228, 229, 230, 250, 251, 252, 253, 254, 256, 257, 279, 280, 281, 282, 285, 294, 306, 307, 309, 310, 313, 334, 337, 352, 353, 354, 355, 358, 360, 380, 382, 383, 386, 392, 406, 408, 409, 410, 411, 414, 418 |
| 3D-footprint Homologues: | 6jnm_A, 8cuc_F, 6ml4_A, 8gn3_A, 5kkq_D, 1ubd_C, 5ei9_F, 1mey_C, 5kl3_A, 8ssq_A, 7w1m_H, 2gli_A, 5k5l_F, 8ssu_A, 8h9h_G, 7eyi_G, 2i13_A, 6e94_A, 7ysf_A, 6wmi_A, 2lt7_A, 6a57_A, 2jpa_A, 7y3l_A, 7n5w_A, 3uk3_C, 1tf3_A, 1tf6_A, 4x9j_A, 6u9q_A, 5yel_A, 7txc_E, 2kmk_A, 1g2f_F, 4m9v_C, 5v3j_F, 1llm_D, 2wbs_A, 5yj3_D, 5k5i_A, 5und_A, 2drp_D, 6blw_A, 1f2i_J, 7y3m_I |
| Binding Motifs: | UN0208.1 / ZNF597_2 sgcCGCCATyTTGd ZNF597_methyl_1 GGCGGCCATyTTGk UN0208.2 gcCGCCATyTTG |
| Related annotations: | PaperBLAST |
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