Transcription Factor

Accessions: 1owr_N (3D-footprint 20231221), 2o93_M (3D-footprint 20231221)
Names: NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1, actor of activated T-cells, cytoplasmic 2
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q13469
Length: 284
Pfam Domains: 16-176 Rel homology domain (RHD)
195-281 IPT/TIG domain
Sequence:
(in bold interface residues)
1 VPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPL 60
61 GLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATID 120
121 CAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSA 180
181 HELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQ 240
241 PNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Interface Residues: 27, 29, 30, 32, 33, 36, 126, 143, 176, 177, 178, 207, 208, 240, 270, 271
3D-footprint Homologues: 1a66_A, 1imh_C, 1p7h_L, 2o61_A, 1nfk_A
Binding Motifs: 1owr_N GGAa
2o93_LMO GGGAnnTTCCGnnnnnnnnnTTCC
2o93_M cGGAa
Binding Sites: 1owr_C
1owr_D
2o93_A
2o93_B
Publications: Stroud J.C, Chen L. Structure of NFAT bound to DNA as a monomer. Journal of molecular biology 334:1009-22 (2003). [Pubmed]

Bates D.L, Barthel K.K, Wu Y, Kalhor R, Stroud J.C, Giffin M.J, Chen L. Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element. Structure (London, England : 1993) 16:684-94 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.