Transcription Factor
Accessions: | 1owr_N (3D-footprint 20231221), 2o93_M (3D-footprint 20231221) |
Names: | NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1, actor of activated T-cells, cytoplasmic 2 |
Organisms: | Homo sapiens |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | Q13469 |
Length: | 284 |
Pfam Domains: | 16-176 Rel homology domain (RHD) 195-281 IPT/TIG domain |
Sequence: (in bold interface residues) | 1 VPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPL 60 61 GLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATID 120 121 CAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSA 180 181 HELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQ 240 241 PNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV |
Interface Residues: | 27, 29, 30, 32, 33, 36, 126, 143, 176, 177, 178, 207, 208, 240, 270, 271 |
3D-footprint Homologues: | 1a66_A, 1imh_C, 1p7h_L, 2o61_A, 1nfk_A |
Binding Motifs: | 1owr_N GGAa 2o93_LMO GGGAnnTTCCGnnnnnnnnnTTCC 2o93_M cGGAa |
Binding Sites: | 1owr_C 1owr_D 2o93_A 2o93_B |
Publications: | Stroud J.C, Chen L. Structure of NFAT bound to DNA as a monomer. Journal of molecular biology 334:1009-22 (2003). [Pubmed] Bates D.L, Barthel K.K, Wu Y, Kalhor R, Stroud J.C, Giffin M.J, Chen L. Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element. Structure (London, England : 1993) 16:684-94 (2008). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.