Transcription Factor

Accessions: 2nll_B (3D-footprint 20231221)
Names: c-erbA-2, c-erbA-beta, Nuclear receptor subfamily 1 group A member 2, THB_HUMAN, THYROID HORMONE RECEPTOR, Thyroid hormone receptor beta
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P10828
Length: 103
Pfam Domains: 3-72 Zinc finger, C4 type (two domains)
Sequence:
(in bold interface residues)
1 DELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQE 60
61 CRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELEK
Interface Residues: 12, 13, 15, 16, 22, 23, 25, 26, 29, 30, 56, 80, 82, 85
3D-footprint Homologues: 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A
Binding Motifs: 2nll_AB GGtnAnnnnaGGTCA
2nll_B hGACCy
Binding Sites: 2nll_D
2nll_C
Publications: Rastinejad F., Perlmann T., Evans R. M., Sigler P. B. Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature 375:203-211 (1995). [Pubmed]
Related annotations: PaperBLAST

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