Transcription Factor
Accessions: | 1a3q_A (3D-footprint 20231221), 1a3q_B (3D-footprint 20231221) |
Names: | DNA-binding factor KBF2, H2TF1, Lymphocyte translocation chromosome 10 protein, Lyt10, NFKB2_HUMAN, NUCLEAR FACTOR KAPPA-B P52, Nuclear factor NF-kappa-B p100 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, Oncogene Lyt-10 |
Organisms: | Homo sapiens |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | Q00653 |
Length: | 285 |
Pfam Domains: | 4-178 Rel homology domain (RHD) |
Sequence: (in bold interface residues) | 1 GPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLV 60 61 THSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQR 120 121 QRLRSRPQGLTEAEQRELEQEAKELKKVMDLSIVRLRFSAFLRSLPLKPVISQPIHDSKS 180 181 PGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVH 240 241 KQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYP |
Interface Residues: | 16, 18, 19, 21, 22, 24, 25, 26, 173, 179, 181, 210, 241 |
3D-footprint Homologues: | 1gji_A, 2ram_A, 1imh_C, 7cli_B, 1nfk_A, 1a3q_A, 2o61_A |
Binding Motifs: | 1a3q_A GGGGaa 1a3q_AB GGGGATTCCCC |
Binding Sites: | 1a3q_C 1a3q_D |
Publications: | Cramer P, Larson C.J, Verdine G.L, Müller C.W. Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution. The EMBO journal 16:7078-90 (1997). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.