Transcription Factor
Accessions: | 1gt0_C (3D-footprint 20231221) |
Names: | NF-A1, Oct-1, Octamer-binding protein 1, OCTAMER-BINDING TRANSCRIPTION FACTOR 1, OTF-1, PO2F1_HUMAN, POU domain, class 2, transcription factor 1 |
Organisms: | Homo sapiens |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | P14859 |
Length: | 137 |
Pfam Domains: | 3-73 Pou domain - N-terminal to homeobox domain 81-137 Homeobox domain |
Sequence: (in bold interface residues) | 1 PSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMSK 60 61 LKPLLEKWLNDAENLGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNME 120 121 KEVIRVWFSNRRQKEKR |
Interface Residues: | 25, 41, 42, 43, 44, 46, 47, 53, 57, 80, 81, 82, 83, 84, 85, 122, 123, 125, 126, 129, 130, 133, 134, 137 |
3D-footprint Homologues: | 3d1n_M, 7u0g_M, 3l1p_A, 1o4x_A, 7xrc_C, 7xzx_N, 1e3o_C, 1au7_A, 3q05_B, 7xzz_N, 2xsd_C, 8g87_X, 3a01_E, 5zjt_E, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 5zfz_A, 1ig7_A, 2lkx_A, 1zq3_P, 7q3o_C, 6es3_K, 1nk2_P, 5hod_A, 2hdd_A, 2r5y_A, 4xrs_G, 2hos_A, 1b72_A, 3rkq_B, 2d5v_B, 6m3d_C, 5jlw_D, 2ld5_A, 1le8_A, 1du0_A, 4cyc_A, 2h1k_B, 1jgg_B, 7psx_B, 3lnq_A, 4qtr_D, 5flv_I |
Binding Motifs: | 1gt0_CD CTTTGTnnGGATGCTAAT |
Publications: | Reményi A, Lins K, Nissen L.J, Reinbold R, Schöler H.R, Wilmanns M. Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. Genes & development 17:2048-59 (2003). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.