Transcription Factor

Accessions: 6e8c_A (3D-footprint 20231221)
Names: Double homeobox protein 10, Double homeobox protein 4, DUX4_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q9UBX2
Length: 134
Pfam Domains: 5-58 Homeobox domain
25-57 Homeobox KN domain
79-133 Homeobox domain
102-132 Homeobox KN domain
Sequence:
(in bold interface residues)
1 RGRGRRRRLVWTPSQSEALRAFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLR 60
61 QHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPES 120
121 RIQIWFQNRRARHP
Interface Residues: 5, 8, 33, 45, 46, 48, 49, 52, 53, 56, 57, 67, 73, 79, 80, 81, 82, 120, 121, 123, 124, 127, 128, 131, 132
3D-footprint Homologues: 3d1n_M, 5zfz_A, 1au7_A, 1qpi_A, 4xrm_B, 8g87_X, 3l1p_A, 6m3d_C, 3a01_E, 1puf_A, 6a8r_A, 3cmy_A, 2h1k_B, 1fjl_B, 1ig7_A, 3lnq_A, 1jgg_B, 2lkx_A, 1nk2_P, 1zq3_P, 2ld5_A, 7q3o_C, 5jlw_D, 3rkq_B, 1puf_B, 6es3_K, 4xrs_G, 2hdd_A, 4cyc_A, 2r5y_A, 5flv_I, 2hos_A, 1b72_A, 5zjt_E, 7psx_B, 5hod_A, 1e3o_C, 1le8_A, 1du0_A, 4qtr_D
Binding Motifs: 6e8c_A TTGATnAnATTAC
Binding Sites: 6e8c_B
6e8c_C
Publications: Lee JK, Bosnakovski D, Toso EA, Dinh T, Banerjee S, Bohl TE, Shi K, Orellana K, Kyba M, Aihara H. Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA. Cell Rep 25:2955-2962 (2018). [Pubmed]
Related annotations: PaperBLAST

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