Transcription Factor

						

			
Accessions: 6e8c_A (3D-footprint 20231221)

			
Names: Double homeobox protein 10, Double homeobox protein 4, DUX4_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q9UBX2
Length: 134
Pfam Domains:      5-58 Homeobox domain
    25-57 Homeobox KN domain
   79-133 Homeobox domain
  102-132 Homeobox KN domain
Sequence: 
(in bold interface residues)		   1 RGRGRRRRLVWTPSQSEALRAFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLR   60
  61 QHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPES  120
 121 RIQIWFQNRRARHP
Interface Residues: 5, 8, 33, 45, 46, 48, 49, 52, 53, 56, 57, 67, 73, 79, 80, 81, 82, 120, 121, 123, 124, 127, 128, 131, 132
3D-footprint Homologues: 3d1n_M, 5zfz_A, 1au7_A, 1qpi_A, 8g87_X, 3l1p_A, 4xrm_B, 6m3d_C, 3a01_E, 2h1k_B, 1fjl_B, 1ig7_A, 1puf_A, 6a8r_A, 3cmy_A, 1jgg_B, 2lkx_A, 1nk2_P, 1zq3_P, 3lnq_A, 2ld5_A, 7q3o_C, 5jlw_D, 3rkq_B, 1puf_B, 6es3_K, 4xrs_G, 2hdd_A, 4cyc_A, 2r5y_A, 5flv_I, 2hos_A, 1b72_A, 5zjt_E, 7psx_B, 5hod_A, 1e3o_C, 1le8_A, 4qtr_D, 1du0_A
Binding Motifs: 6e8c_A TTGATnAnATTAC
Binding Sites: 6e8c_B
6e8c_C
			
Publications: Lee JK, Bosnakovski D, Toso EA, Dinh T, Banerjee S, Bohl TE, Shi K, Orellana K, Kyba M, Aihara H. Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA. Cell Rep 25:2955-2962 (2018). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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