Transcription Factor
| Accessions: | 5od6_A (3D-footprint 20231221) |
| Names: | hMAD-3, hSMAD3, JV15-2, MAD homolog 3, Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, SMAD 3, SMAD family member 3, SMAD3_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P84022 |
| Length: | 125 |
| Pfam Domains: | 22-122 MH1 domain |
| Sequence: (in bold interface residues) | 1 MIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPR 60 61 SLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQR 120 121 VETPV |
| Interface Residues: | 22, 24, 28, 63, 65, 67, 70, 72 |
| 3D-footprint Homologues: | 8cli_A, 6fzs_A, 6h3r_A, 5nm9_A, 5od6_A, 5mey_A, 2qnf_A |
| Binding Motifs: | 5od6_A CGcC |
| Binding Sites: | 5od6_C / 5od6_D |
| Publications: | Martin-Malpartida P, Batet M, Kaczmarska Z, Freier R, Gomes T, Aragón E, Zou Y, Wang Q, Xi Q, Ruiz L, Vea A, Márquez JA, Massagué J, Macias MJ. Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun 8:2070 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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