Transcription Factor

						

			
Accessions: 2h8r_B (3D-footprint 20231221)

			
Names: Hepatocyte nuclear factor 1-beta, HNF-1-beta, HNF-1B, HNF1B_HUMAN, Homeoprotein LFB3, TCF-2, Transcription factor 2, Variant hepatic nuclear factor 1, vHNF1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P35680
Length: 176
Pfam Domains:      2-93 Hepatocyte nuclear factor 1 (HNF-1), N terminus
   98-171 Homeobox domain
Sequence: 
(in bold interface residues)		   1 SILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSH   60
  61 LSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFNQMRRNRFKWGPASQQILYQAYDRQK  120
 121 NPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFR
Interface Residues: 57, 58, 59, 60, 62, 63, 69, 70, 79, 98, 101, 161, 162, 163, 164, 167, 168, 171
3D-footprint Homologues: 1ic8_B, 4on0_B, 2h8r_B, 5zfz_A, 1fjl_B, 4j19_B, 1le8_A
Binding Motifs: 2h8r_AB tGGTGAATtATTAAC
2h8r_B TAATnntTcACCa
Binding Sites: 2h8r_E
2h8r_F
			
Publications: Lu P, Rha G.B, Chi Y.I. Structural basis of disease-causing mutations in hepatocyte nuclear factor 1beta. Biochemistry 46:12071-80 (2007). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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