DNA Binding Motif

						

			
Accessions: 2h8r_B (3D-footprint 20231221)

			
Names: Hepatocyte nuclear factor 1-beta
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Hepatocyte Nuclear Factor 1b bound to DNA: MODY5 Gene Product
Length: 13
Consensus: TAATnntTcACCa
Weblogo: 
PSSM: P0      A      C      G      T
01      0      0      0     96      T
02     84      3      6      3      A
03     96      0      0      0      A
04      0      0      0     96      T
05     24     24     24     24      n
06     24     24     24     24      n
07      7     11     14     64      t
08      8     11     11     66      T
09     11     62     11     12      c
10     96      0      0      0      A
11      0     96      0      0      C
12      0     96      0      0      C
13     62     11     12     11      a
Binding TFs: 2h8r_B (Homeobox domain, Hepatocyte nuclear factor 1 (HNF-1), N terminus)
Binding Sites: 2h8r_E
2h8r_F
			
Publications: Lu P, Rha G.B, Chi Y.I. Structural basis of disease-causing mutations in hepatocyte nuclear factor 1beta. Biochemistry 46:12071-80 (2007). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.