Transcription Factor
| Accessions: | UP00368A (UniPROBE 20160601) |
| Names: | HLH-29 |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q19917 |
| Description: | Helix Loop Helix Protein 29: hlh-29 encodes a REF-1-like protein with two bHLH domains that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-26, and HLH-27) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-26, HLH-27, and perhaps HLH-28); HLH-29 is identical to residues 24-262 of HLH-28, shares near-identical promoter regions in a inverted duplex, and is likely to be highly redundant with HLH-28; HL |
| Length: | 238 |
| Pfam Domains: | 23-66 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 PKVHQATFPKASVHSVPYNQTRKSVSERKRRDEINELLENLKTIVQNPSDSNEKISHETI 60 61 LFRVFERVSGVDLETKFNSTVDIPKAEGNTKEEKQKVKTKREQIRRSKQDICYTELGNFV 120 121 HKNRLGNTEQRNKLERVTVLQIILEYICQMPEQSEAIEKENSPMYQVYLEPTKCISPEQS 180 181 VASPSPFLLSNTLAFFNQVAQLHFIAKLQAMLPPTPVQTPEAHMKEQTNEEEDIDIIG |
| Interface Residues: | 21, 26, 27, 30, 31, 36, 39, 40 |
| 3D-footprint Homologues: | 6rwn_I, 8osl_O, 4h10_A, 8osl_P, 5eyo_A |
| Binding Motifs: | UP00368A_1 cwrhyACGCrTGkyhwa |
| Binding Sites: | AACACGCG ACACGCGT ACATGCGT ACCACGCG ACCATGCG ACGCATGG ACGCGTGG CACGCATG CACGCGTA CACGCGTC CACGCGTG CATGCGTA CATGCGTC CGCATGGC CGCATGTC CGCGTGGC CGCGTGTC AACATGCG AACGCATG ACGCATGA |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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