Transcription Factor
Accessions: | 4r2e_A (3D-footprint 20231221), 5kl2_A (3D-footprint 20231221) |
Names: | Wilms tumor protein, isoform 4/CRA_a, WT1_HUMAN, WT33, Wilms tumor protein |
Organisms: | Homo sapiens |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | P19544 |
Length: | 88 |
Pfam Domains: | 4-28 C2H2-type zinc finger 4-28 Zinc finger, C2H2 type 21-45 Zinc-finger double domain 34-54 Zinc-finger of C2H2 type 34-56 C2H2-type zinc finger 34-56 Zinc finger, C2H2 type 48-74 Zinc-finger double domain 62-86 Zinc finger, C2H2 type 62-84 C2H2-type zinc finger |
Sequence: (in bold interface residues) | 1 EKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEK 60 61 PFSCRWPSCQKKFARSDELVRHHNMHQR |
Interface Residues: | 16, 17, 18, 19, 20, 22, 23, 44, 45, 46, 47, 48, 50, 51, 52, 70, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82 |
3D-footprint Homologues: | 6ml4_A, 7n5w_A, 6jnm_A, 8cuc_F, 1tf3_A, 7y3l_A, 2gli_A, 1g2f_F, 6blw_A, 5kkq_D, 1tf6_A, 6u9q_A, 4x9j_A, 2i13_A, 5kl3_A, 2wbs_A, 1ubd_C, 7ysf_A, 5ei9_F, 2jpa_A, 8ssq_A, 1mey_C, 7w1m_H, 5und_A, 2drp_D, 1f2i_J, 7eyi_G, 5k5i_A, 2kmk_A, 8ssu_A, 5v3j_F, 8h9h_G, 2lt7_A, 7y3m_I, 6e94_A, 6wmi_A, 6a57_A, 8gn3_A, 3uk3_C, 5yel_A, 1llm_D, 7txc_E, 5yj3_D, 4m9v_C |
Binding Motifs: | 4r2e_A GCGTGGGcGG 5kl2_A aCTCCCACGC |
Binding Sites: | 4r2e_C 5kl2_B 5kl2_C 4r2e_B |
Publications: | Hashimoto H, Olanrewaju Y.O, Zheng Y, Wilson G.G, Zhang X, Cheng X. Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. Genes & development 28:2304-13 (2014). [Pubmed] Hashimoto H, Zhang X, Zheng Y, Wilson GG, Cheng X. Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications. Nucleic Acids Res 44:10165-10176 (2016). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.