Transcription Factor

						

			
Accessions: FOS_TF1 (HumanTF2 1.0), FOS (HT-SELEX2 May2017)

			
Names: Cellular oncogene fos, FOS, FOS_HUMAN, G0/G1 switch regulatory protein 7, Proto-oncogene c-Fos, ENSG00000170345
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, HT-SELEX2 May2017 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Uniprot: P01100
Notes: Ensembl ID: ENSG00000170345; Construct type: TF1(SBP); TF family: bZIP; Clone source: MGC, TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3
Length: 142
Pfam Domains:    62-121 bZIP transcription factor
   64-116 Basic region leucine zipper
Sequence: 
(in bold interface residues)		   1 QWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLS   60
  61 PEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKL  120
 121 EFILAAHRPACKIPDDLGFPEE
Interface Residues: 70, 71, 74, 75, 77, 78, 81, 82, 85
3D-footprint Homologues: 7x5e_F, 2wt7_A, 7x5e_E, 1skn_P, 6mg1_B, 5vpe_C, 5vpe_D, 4eot_A
Binding Motifs: FOS bgATGACGTCATCr
FOS_2 gATGACGTCAyc
FOS_methyl_1 gATGAyGTCATc
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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