DNA Binding Motif

						

			
Accessions: FOS (HumanTF2 1.0), MA1951.1 (JASPAR 2024)

			
Names: FOS
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: HT-SELEX; HT-SELEX generated reference PWM, HT-SELEX
Length: 14
Consensus: bgATGACGTCATCr
Weblogo: 
PSSM: P0      A      C      G      T
01    226    460    466    525      b
02    262    364   1283    394      g
03   1519     77    517     33      A
04      3     10     16   1675      T
05     39     38   1647     60      G
06   1672     14     35      4      A
07     10   1663      2     80      C
08     50      2   1666     14      G
09     24      0     29   1669      T
10    110   1634     22     30      C
11   1671      0     18      0      A
12     19    345     49   1549      T
13    253   1515    152    145      C
14    847     73    805     51      r
Type: Heterodimer
Binding TFs: P01100 (bZIP transcription factor, Basic region leucine zipper)
FOS_TF1 (bZIP transcription factor, Basic region leucine zipper)
P01100
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Nakabeppu Y., Nathans D. The basic region of Fos mediates specific DNA binding. EMBO J. 8:3833-3841 (1989). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.