Transcription Factor
| Accessions: | 1le5_B (3D-footprint 20231221), 1le5_F (3D-footprint 20231221) |
| Names: | DNA-binding factor KBF1, EBP-1, NF-kappa-B1 p84/NF-kappa-B1 p98, NFKB1_MOUSE, Nuclear factor NF-kappa-B p105 subunit, Nuclear factor NF-kappa-B p50 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| Organisms: | Mus musculus |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P25799 |
| Length: | 313 |
| Pfam Domains: | 5-203 Rel homology domain (RHD) |
| Sequence: (in bold interface residues) | 1 MGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQL 60 61 VTNGKNIHLHAHSLVGKHCEDGVCTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTE 120 121 ACIRGYNPGLLVHSDLAYLQAEGGGDRQLTDREKEIIRQAAVQQTKEMDLSVVRLMFTAF 180 181 LPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDD 240 241 IQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDL 300 301 ETSEPKPFLYYPE |
| Interface Residues: | 17, 19, 20, 22, 23, 25, 26, 27, 204, 206, 235, 268, 295, 296 |
| 3D-footprint Homologues: | 1a3q_A, 2o61_A, 1gji_A, 2ram_A, 1nfk_A, 7cli_B, 1p7h_L |
| Binding Motifs: | 1le5_AB TGGAATTTCCC 1le5_EF GGGAantTCC |
| Binding Sites: | 1le5_C / 1le5_G 1le5_D / 1le5_H |
| Publications: | Berkowitz B, Huang D.B, Chen-Park F.E, Sigler P.B, Ghosh G. The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site. The Journal of biological chemistry 277:24694-700 (2002). [Pubmed] |
| Related annotations: | PaperBLAST |
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