Transcription Factor
| Accessions: | O00712 (JASPAR 2024) |
| Names: | CCAAT-box-binding transcription factor, CTF, NF-I/B, NF1-B, NFI-B, NFIB_HUMAN, Nuclear factor 1 B-type, Nuclear factor 1/B, Nuclear factor I/B, TGGCA-binding protein |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | O00712 |
| Length: | 420 |
| Pfam Domains: | 5-47 Nuclear factor I protein pre-N-terminus 70-171 MH1 domain 209-415 CTF/NF-I family transcription modulation region |
| Sequence: (in bold interface residues) | 1 MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDE 60 61 LLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDC 120 121 LRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFL 180 181 AYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFP 240 241 IGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGS 300 301 RTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTP 360 361 PPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQSWYLG 420 |
| Interface Residues: | 40, 43, 44, 48 |
| 3D-footprint Homologues: | 2lkx_A |
| Binding Motifs: | MA1643.1 trcCTGGCAykgTGCCAagha MA1643.2 cCTGGCAykgTGCCAag |
| Binding Sites: | MA1643.1.1 MA1643.1.10 / MA1643.1.4 MA1643.1.11 MA1643.1.12 MA1643.1.13 / MA1643.1.5 MA1643.1.14 MA1643.1.15 MA1643.1.16 / MA1643.1.6 MA1643.1.17 MA1643.1.18 / MA1643.1.7 MA1643.1.19 MA1643.1.1 / MA1643.1.2 MA1643.1.20 MA1643.1.3 MA1643.1.2 / MA1643.1.4 MA1643.1.5 MA1643.1.3 / MA1643.1.6 MA1643.1.7 MA1643.1.8 MA1643.1.9 MA1643.1.10 MA1643.1.11 MA1643.1.12 MA1643.1.13 MA1643.1.14 MA1643.1.15 MA1643.1.16 MA1643.1.17 MA1643.1.18 MA1643.1.19 MA1643.1.20 MA1643.1.8 MA1643.1.9 MA1643.2.1 MA1643.2.10 MA1643.2.11 MA1643.2.12 MA1643.2.13 MA1643.2.14 MA1643.2.15 MA1643.2.16 MA1643.2.17 MA1643.2.18 MA1643.2.19 MA1643.2.2 MA1643.2.20 MA1643.2.3 MA1643.2.4 MA1643.2.5 MA1643.2.6 MA1643.2.7 MA1643.2.8 MA1643.2.9 |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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