Transcription Factor
| Accessions: | MEIS2_HUMAN (HOCOMOCO 10), O14770 (JASPAR 2024) |
| Names: | Homeobox protein Meis2, Meis1-related protein 1, MEIS2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 477 |
| Pfam Domains: | 278-333 Homeobox domain 294-333 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV 60 61 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN 120 121 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK 180 181 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH 240 241 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT 300 301 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS 360 361 PEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLR 420 421 HGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ |
| Interface Residues: | 276, 277, 279, 280, 324, 325, 328, 329, 330, 332, 333, 364, 367 |
| 3D-footprint Homologues: | 4j19_B, 6fqp_B, 1puf_B, 1au7_A, 7q3o_C, 1le8_A, 1le8_B, 5zfz_A, 3cmy_A, 1fjl_B, 4xrm_B, 1mnm_C, 6a8r_A, 3lnq_A, 1k61_B, 8g87_X, 4xrs_G, 3rkq_B, 5hod_A, 2d5v_B, 6fqq_E |
| Binding Motifs: | MA0774.1 tTGACAGs MEIS2_HUMAN.H10MO.B|M01324 tTGACAGsTkTcm MA1640.1 raaTGATTTATgryy MA1640.2 TGATTTATg |
| Binding Sites: | MA1640.1.1 MA1640.1.10 / MA1640.1.7 MA1640.1.11 MA1640.1.12 / MA1640.1.8 MA1640.1.13 / MA1640.1.9 MA1640.1.10 / MA1640.1.14 MA1640.1.11 / MA1640.1.15 MA1640.1.12 / MA1640.1.16 MA1640.1.13 / MA1640.1.17 MA1640.1.14 / MA1640.1.18 MA1640.1.15 / MA1640.1.19 MA1640.1.1 / MA1640.1.2 MA1640.1.16 / MA1640.1.20 MA1640.1.2 / MA1640.1.3 MA1640.1.4 MA1640.1.5 MA1640.1.6 MA1640.1.7 MA1640.1.8 MA1640.1.5 / MA1640.1.9 MA1640.1.17 MA1640.1.18 MA1640.1.19 MA1640.1.20 MA1640.1.3 MA1640.1.6 MA1640.2.5 MA1640.2.1 MA1640.2.10 MA1640.2.11 / MA1640.2.4 MA1640.2.12 MA1640.2.13 MA1640.2.14 / MA1640.2.17 MA1640.2.15 MA1640.2.16 MA1640.2.18 MA1640.2.19 MA1640.2.2 / MA1640.2.9 MA1640.2.20 MA1640.2.3 MA1640.2.6 MA1640.2.7 MA1640.2.8 |
| Publications: | Knoepfler P. S., Calvo K. R., Chen H., Antonarakis S. E., Kamps M. P. Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc. Natl. Acad. Sci. USA 94:14553-14558 (1997). [Pubmed] Penkov D, Mateos San Martín D, Fernandez-Díaz LC, Rosselló CA, Torroja C, Sánchez-Cabo F, Warnatz HJ, Sultan M, Yaspo ML, Gabrieli A, Tkachuk V, Brendolan A, Blasi F, Torres M. Analysis of the DNA-binding profile and function of TALE homeoproteins reveals their specialization and specific interactions with Hox genes/proteins. Cell Rep 3:1321-33 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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