Transcription Factor

Accessions: UP00519A (UniPROBE 20160601)
Names: D.mel FoxN1/4, DOMINA protein, Jumeau, Winged-helix nude transcription factor, Winged-helix protein
Organisms: Drosophila melanogaster
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 719
Pfam Domains: 411-502 Fork head domain
Sequence:
(in bold interface residues)
1 MFELEDYSSGIHEGFFSKYADAAGPSLDFYVSDSMQEMLNVDIRAEIANVVGSSSSDLTS 60
61 SLDQTLEAISAINNNQSNGNSSQSASYNANANFLTSSGLHASPTAKWMGSSANFWSNSDY 120
121 YADLGACVNPISVMPLINSTSAGMFSPKKNKTASSTQGRSGAVPSSPSAERDQHKSHLTF 180
181 SPAQMKVSAGSMRRDQVMAHIPKQISVVTGTGTTAPATMATNSVLQRRNSSAVDAVRKDL 240
241 VTELRKAQSSPVPNSLEELGKGKGSTLLNASVGATNTIKLAPGIGGLTFANSAAYQKLKQ 300
301 TSLVKSPGGISPGAGSNMGLKREDSNKRGLQASTTPKSIASAANSPHHQMQSNYSLGSPS 360
361 SLSSSSASSPLGNVSNLVNIANNNTSGAGSGLVKPLQQKVKLPPVGSPFPKPAYSYSCLI 420
421 ALALKNSRAGSLPVSEIYSFLCQHFPYFENAPSGWKNSVRHNLSLNKCFEKIERPATNGN 480
481 QRKGCRWAMNPDRINKMDEEVQKWSRKDPAAIRGAMVYPQHLESLERGEMKHGSADSDVE 540
541 LDSQSEIEESSDLEEHEFEDTMVDAMLVEEEDEEEDGDDDEQIINDFDAEDERHANGNQA 600
601 NNLPINHPLLGQKSNDFDIEVGDLYDAIDIEDDKESVRRIISNDQHIIELNPADLNATDG 660
661 YNQQPALKRARVDINYAIGPAGELEQQYGQKVKVQQVIQPQQHPPTYNRRKMPLVNRVI
Interface Residues: 451, 454, 456, 457, 458, 460, 461, 462, 464, 465, 476, 483
3D-footprint Homologues: 3l2c_A, 7vox_H, 2hdc_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 3qrf_G
Binding Motifs: UP00519A_1 agmwywragyGACGCgbmvtya
UP00519A_2 tskgytvATgGCGTCykgamwy
Binding Sites: ACGCGTCA
ACGCGTCG
GACGCGTA
AAGCGTCA
ATCGCGTC
ATGACGCC
ATGACGCG
ATGGCGTC
CCGACGCG
CGACGCGC
CGACGCTA
CGCGTCGC
GACGCCGC
GACGCTAC
GCGACGCC
GCGTCATA
GGCGTCAC
TAGCGTCA
TCGCGTCA
TGACGCCA
Publications: Nakagawa S, Gisselbrecht SS, Rogers JM, Hartl DL, Bulyk ML. DNA-binding specificity changes in the evolution of forkhead transcription factors. Proc Natl Acad Sci U S A 110:12349-54 (2013). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.