Transcription Factor

						

			
Accessions: 5wc9_F (3D-footprint 20231221)

			
Names: GHF-1, Growth hormone factor 1, PIT-1, PIT1_HUMAN, Pituitary-specific positive transcription factor 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P28069
Length: 132
Pfam Domains:      2-74 Pou domain - N-terminal to homeobox domain
   75-130 Homeobox domain
Sequence: 
(in bold interface residues)		   1 DSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNAC   60
  61 KLKAILSKWLEEAEQRRTTISIAAKDALERHFGEQNKPSSQEIMRMAEELNLEKEVVRVW  120
 121 FCNRRQREKRVK
Interface Residues: 26, 42, 43, 44, 45, 47, 48, 50, 51, 54, 58, 74, 75, 77, 115, 116, 118, 119, 122, 123, 126, 127, 130
3D-footprint Homologues: 3l1p_A, 7u0g_M, 3d1n_M, 1o4x_A, 1e3o_C, 7xrc_C, 1au7_A, 8g87_X, 2xsd_C, 2d5v_B, 5zfz_A, 1nk2_P, 6a8r_A, 2h1k_B, 1jgg_B, 3lnq_A, 2lkx_A, 4xrs_G, 3cmy_A, 2hdd_A, 3rkq_B, 2r5y_A, 1fjl_B, 5flv_I, 2hos_A, 1b72_A, 1ig7_A, 5hod_A, 2ld5_A, 5jlw_D, 1le8_A, 7q3o_C, 1du0_A, 4qtr_D, 3a01_E, 1puf_A, 6es3_K, 1zq3_P, 7psx_B, 5zjt_E, 4cyc_A
Binding Motifs: 5wc9_EF TTCATTCATTCAT
Binding Sites: 5wc9_G
5wc9_H
			
Publications: Agarwal S, Cho TY. Biochemical and structural characterization of a novel cooperative binding mode by Pit-1 with CATT repeats in the macrophage migration inhibitory factor promoter. Nucleic Acids Res : (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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