DNA Binding Motif

						

			
Accessions: 5wc9_EF (3D-footprint 20231221)

			
Names: Pituitary-specific positive transcription factor 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Human Pit-1 and 4xCATT DNA complex
Length: 13
Consensus: TTCATTCATTCAT
Weblogo: 
PSSM: P0      A      C      G      T
01      0      0      0     96      T
02      0      0      0     96      T
03      0     96      0      0      C
04     96      0      0      0      A
05      0      0      0     96      T
06      9     14      7     66      T
07      7     73      7      9      C
08     96      0      0      0      A
09      0      0     14     82      T
10      8      0      7     81      T
11      0     96      0      0      C
12     96      0      0      0      A
13      0      7      7     82      T
Type: Heterodimer
Binding TFs: 5wc9_E (Homeobox domain, Pou domain - N-terminal to homeobox domain)
5wc9_F (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Binding Sites: 5wc9_G
5wc9_H
			
Publications: Agarwal S, Cho TY. Biochemical and structural characterization of a novel cooperative binding mode by Pit-1 with CATT repeats in the macrophage migration inhibitory factor promoter. Nucleic Acids Res : (2017). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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