DNA Binding Motif

						

			
Accessions: 6b0o_A (3D-footprint 20231221)

			
Names: Wilms tumor protein
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Zinc finger Domain of WT1(-KTS form) with 12+1mer Oligonucleotide with 3' Triplet TGT
Length: 12
Consensus: GCGTGGGAGTGt
Weblogo: 
PSSM: P0      A      C      G      T
01      0     19     77      0      G
02      0     96      0      0      C
03      0      0     96      0      G
04      0      0      0     96      T
05      0      0     96      0      G
06      0      0     96      0      G
07      0      0     96      0      G
08     96      0      0      0      A
09      0      0     96      0      G
10      0      0      0     96      T
11      0      0     96      0      G
12     19     20     19     38      t
Binding TFs: 6b0o_A (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Binding Sites: 6b0o_B
6b0o_C
			
Publications: Wang D, Horton JR, Zheng Y, Blumenthal RM, Zhang X, Cheng X. Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites. Nucleic Acids Res 46:3864-3877 (2018). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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