DNA Binding Motif

						

			
Accessions: HOXA9_3 (HT-SELEX2 May2017), MA0594.2 (JASPAR 2024)

			
Names: HOXA9
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 10
Consensus: rtCRTwAays
Weblogo: 
PSSM: P0      A      C      G      T
01    651    381    993     33      r
02    277    534    145   1644      t
03     77   1644     16     71      C
04    627     17   1644      0      R
05      0     47      0   1644      T
06   1644    123     74   1262      w
07   1644     86     23    177      A
08   1644    874    215    875      a
09    370    485    336    453      y
10    350    449    498    347      s
Type: Heterodimer
Binding TFs: HOXA9 / P31269 (Homeobox domain, Hox9 activation region    )
P31269
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


LaRonde-LeBlanc N.A, Wolberger C. Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. Genes & development 17:2060-72 (2003). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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