DNA Binding Motif

						

			
Accessions: SOX8_2 (HT-SELEX2 May2017), MA0868.2 (JASPAR 2024)

			
Names: SOX8
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 10
Consensus: agAACAATrg
Weblogo: 
PSSM: P0      A      C      G      T
01   1827   1124    854    724      a
02    740    414   1827    571      g
03   1827    151    263    222      A
04   1827      0      0     45      A
05      3   1827     35     70      C
06   1827      0      0     16      A
07   1827     43      0     36      A
08    273     36     20   1827      T
09   1356    208   1827    287      r
10    300    421    912    193      g
Type: Heterodimer
Binding TFs: SOX8 (HMG (high mobility group) box, Domain of unknown function (DUF1898))
P57073 (HMG (high mobility group) box, Domain of unknown function (DUF1898), Sox developmental protein N terminal )
P57073
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Stros M, Launholt D, Grasser KD. The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins. Cell Mol Life Sci : (2007). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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