Transcription Factor
| Accessions: | SOX8_DBD (HumanTF 1.0), SOX8 (HT-SELEX2 May2017) |
| Names: | SOX8, SOX8_HUMAN, ENSG00000005513 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P57073 |
| Notes: | Ensembl ID: ENSG00000005513; DNA-binding domain sequence; TF family: HMG; Clone source: Gene synthesis, TF family: HMG experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: HMG experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: HMG experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2, TF family: HMG experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 107 |
| Pfam Domains: | 21-89 HMG (high mobility group) box 22-84 Domain of unknown function (DUF1898) |
| Sequence: (in bold interface residues) | 1 SLVPMPVRGGGGGALKAKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWR 60 61 LLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSAKAGHSDSDS |
| Interface Residues: | 23, 26, 28, 29, 32, 36, 47, 48, 49, 52, 90, 94 |
| 3D-footprint Homologues: | 3u2b_C, 2gzk_A, 4s2q_D, 1j5n_A, 2lef_A, 4y60_C, 1o4x_B, 3f27_D, 7m5w_A, 1qrv_A, 1hry_A |
| Binding Motifs: | SOX8_DBD_1 AACAATrTGCAGTGTT SOX8_DBD_2 ATGAATTkCAGTC SOX8_DBD_3 rAACAATTkCAGTGTTy SOX8_DBD_4 cATCAATTgCAGTGATy SOX8_DBD_5 TGAATrTkCAGTCA SOX8_2 agAACAATrg SOX8_4 ACAATrgvbcyATTGT SOX8_methyl_1 agaACAATrs SOX8_methyl_3 ACAATrrvycyATTGT |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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