DNA Binding Motif

						

			
Accessions: IRX3_2 (HT-SELEX2 May2017), UN0130.1 (JASPAR 2024)

			
Names: IRX3
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 18
Consensus: wACAyGawwwwtCrTGTw
Weblogo: 
PSSM: P0      A      C      G      T
01   3636      2   2284   6765      w
02  12686     73      0     34      A
03     18  12686      1    154      C
04  12686      0      2      4      A
05   4569   6163     28  12686      y
06   2319   1454  12686    306      G
07   6019   2038   1858   2773      a
08   5806    791    882   5207      w
09   5789    472    461   5964      w
10   6173    427    481   5606      w
11   5255    916    845   5670      w
12   2958   1832   2056   5840      t
13    370  12686   1342   2021      C
14  12686     24   6050   4491      r
15      0      2      0  12686      T
16    145      5  12686     22      G
17     32      0     74  12686      T
18   6804   2303     15   3566      w
Type: Heterodimer
Binding TFs: IRX3 (Homeobox domain, Homeobox KN domain)
P78415 (Homeobox domain, Homeobox KN domain)
P78415
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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