Transcription Factor
| Accessions: | IRX3 (HT-SELEX2 May2017) |
| Names: | ENSG00000177508, IRX3 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 192 |
| Pfam Domains: | 124-167 Homeobox domain 125-164 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 GAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAPYAAAAAAAAAQGYGAFLPYA 60 61 AELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPYGQYQFGDPSRPKNATRESTS 120 121 TLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTD 180 181 EEGNAYGSEREE |
| Interface Residues: | 110, 111, 112, 113, 114, 115, 118, 152, 153, 155, 156, 159, 160, 161, 163, 164, 166, 167 |
| 3D-footprint Homologues: | 1mnm_C, 1puf_B, 3d1n_M, 1fjl_B, 2h1k_B, 2ld5_A, 5jlw_D, 7xrc_C, 1ig7_A, 1le8_B, 7psx_B, 4xrm_B, 2lkx_A, 1puf_A, 5zjt_E, 2hdd_A, 4xrs_G, 2r5y_A, 6fqp_B, 3rkq_B, 1nk2_P, 1b72_A, 5flv_I, 3a01_E, 2d5v_B, 1k61_B, 6fqq_E, 4cyc_A, 1o4x_A, 1du0_A, 3cmy_A, 2hos_A |
| Binding Motifs: | IRX3_2 wACAyGawwwwtCrTGTw IRX3_methyl_1 wACryrwwwwwwykCGTw |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.