DNA Binding Motif

						

			
Accessions: TFEC_2 (HT-SELEX2 May2017), MA0871.2 (JASPAR 2024)

			
Names: TFEC
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 11
Consensus: msCACGTGACc
Weblogo: 
PSSM: P0      A      C      G      T
01   3273   4679   2355   2725      m
02   1841   2887   2302    922      s
03      0   7952      3      0      C
04   7952      0    145    374      A
05      0   7952      0    210      C
06     69      0   7952      0      G
07      0      0      0   7952      T
08      0      4   7952      0      G
09   7952    411    143     47      A
10     17   6900     58   1052      C
11   1850   2828   1708   1566      c
Type: Heterodimer
Binding TFs: TFEC (Helix-loop-helix DNA-binding domain)
O14948 (Helix-loop-helix DNA-binding domain, Domain of unknown function (DUF3371))
O14948
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Jones S. An overview of the basic helix-loop-helix proteins. Genome Biol : (2004;5(6):226.). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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