DNA Binding Motif

						

			
Accessions: 5cc1_WX (3D-footprint 20231221)

			
Names: Glucocorticoid receptor
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: S425G Glucocorticoid receptor DNA binding domain - (+)GRE complex
Length: 13
Consensus: GnnCAnnntGtnC
Weblogo: 
PSSM: P0      A      C      G      T
01     10      0     86      0      G
02     24     24     24     24      n
03     24     24     24     24      n
04      0     96      0      0      C
05     96      0      0      0      A
06     24     24     24     24      n
07     24     24     24     24      n
08     24     24     24     24      n
09     10     12     10     64      t
10      0      0     96      0      G
11     10     10     12     64      t
12     24     24     24     24      n
13     11     85      0      0      C
Type: Heterodimer
Binding TFs: 5cc1_W (Zinc finger, C4 type (two domains))
5cc1_X (Zinc finger, C4 type (two domains))
Binding Sites: 5cc1_Z
5cc1_Y
			
Publications: Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proc Natl Acad Sci U S A 113:326-31 (2016). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.