DNA Binding Site

						

			
Accessions: 4oor_I (3D-footprint 20231221), 4oor_K (3D-footprint 20231221), 4ov7_I (3D-footprint 20231221), 4ov7_K (3D-footprint 20231221), 4tnt_D (3D-footprint 20231221), 5cbx_C (3D-footprint 20231221), 5cbx_H (3D-footprint 20231221), 5cby_C (3D-footprint 20231221), 5cbz_C (3D-footprint 20231221), 5cbz_G (3D-footprint 20231221), 5cc1_C (3D-footprint 20231221), 5cc1_Z (3D-footprint 20231221)

			
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 17
Sequence: CAGAACAGAGTGTTCTG
Type: Heterodimer
Binding TFs: 4oor_B / 4ov7_B (Zinc finger, C4 type (two domains))
4oor_F / 4ov7_F (Zinc finger, C4 type (two domains))
4tnt_B (Zinc finger, C4 type (two domains))
5cbx_B / 5cbx_F (Zinc finger, C4 type (two domains))
5cbx_E (Zinc finger, C4 type (two domains))
5cby_B (Zinc finger, C4 type (two domains))
5cbz_B (Zinc finger, C4 type (two domains))
5cbz_E (Zinc finger, C4 type (two domains))
5cbz_F (Zinc finger, C4 type (two domains))
5cc1_B / 5cc1_X (Zinc finger, C4 type (two domains))
Binding Motifs: 5cbx_E gnaCA
4oor_AB GnmCAnnnTGnnw
4oor_EF GnaCAnnnTGtnnA
4ov7_AB GnaCAnnnTGnnw
4ov7_EF TnnnCAnnnTGTnC
4tnt_AB GnaCannnTGnnC
4tnt_B aGnACA
5cbx_AB GnnCAnnnTGTnC
5cbx_EF GnrCAnnnTGtna
5cby_AB GnnCAnnnTGtnC
5cby_B gnaCA
5cbz_AB GnnCAnnnTGtnC
5cbz_E TGtnc
5cbz_EF GnrCAnnnTGwnC
5cc1_AB GnnCAnnnTGnnC
5cc1_WX GnnCAnnntGtnC
			
Publications: McKeown A.N, Bridgham J.T, Anderson D.W, Murphy M.N, Ortlund E.A, Thornton J.W. Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module. Cell 159:58-68 (2014). [Pubmed]


Hudson W.H, Youn C, Ortlund E.A. Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. PloS one 9:e107000 (2014). [Pubmed]


Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proc Natl Acad Sci U S A 113:326-31 (2016). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.