DNA Binding Motif

						

			
Accessions: 1l1m_AB (3D-footprint 20231221)

			
Names: Lactose operon repressor
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O1
Length: 17
Consensus: TTGTTATCCGCTCACAA
Weblogo: 
PSSM: P0      A      C      G      T
01      3      4      3     86      T
02      8      6      6     76      T
03      9      9     69      9      G
04      0      0      0     96      T
05      0      0      0     96      T
06     96      0      0      0      A
07      0      4      0     92      T
08      4     86      3      3      C
09      0     96      0      0      C
10      0      0     96      0      G
11      0     96      0      0      C
12      0      0      0     96      T
13      0     96      0      0      C
14     96      0      0      0      A
15      6     76      8      6      C
16     78      6      6      6      A
17     86      4      3      3      A
Binding TFs: 1l1m_A / 1l1m_B (Bacterial regulatory proteins, lacI family)
Binding Sites: 1l1m_C
1l1m_D
			
Publications: Kalodimos C.G, Bonvin A.M, Salinas R.K, Wechselberger R, Boelens R, Kaptein R. Plasticity in protein-DNA recognition: lac repressor interacts with its natural operator 01 through alternative conformations of its DNA-binding domain. The EMBO journal 21:2866-76 (2002). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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