DNA Binding Motif

						

			
Accessions: VDR_full (HumanTF 1.0), MA0693.1 (JASPAR 2024)

			
Names: VDR
Organisms: Homo sapiens, Mus musculus
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 16
Consensus: GrGTTCAyyGrGTTCA
Weblogo: 
PSSM: P0      A      C      G      T
01   5712   1471  23911    173      G
02  20648     11  12584      1      r
03      8      5  28323     11      G
04      5     13   3866  29506      T
05    267    455    919  30107      T
06     43  46948     62    884      C
07  35680    130   3649    210      A
08   3643   8775   1638  19613      y
09   6013  12672   2619  13845      y
10   5903   2186  22959    464      G
11  20690     14  12607      3      r
12      6      2  28372      5      G
13      2      7   2512  29193      T
14    263    391   1241  28965      T
15      7  45781     73   1671      C
16  37729    137   4040    149      A
Type: Heterodimer
Binding TFs: VDR_full (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains))
P48281 (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains))
P48281
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Nishikawa J, Kitaura M, Matsumoto M, Imagawa M, Nishihara T. Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer. Nucleic Acids Res 22:2902-7 (1994). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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