DNA Binding Motif

						

			
Accessions: HOXA13_4 (HT-SELEX2 May2017), MA0650.2 (JASPAR 2024)

			
Names: HOXA13
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 11
Consensus: vCCMATAAAAc
Weblogo: 
PSSM: P0      A      C      G      T
01    294    351    290     18      v
02     63    954    254      0      C
03      0    954      0     54      C
04    954    394      0      0      M
05    954      0      0      0      A
06      0      0      0    954      T
07    954      0     17      0      A
08    954      0      1      0      A
09    954      0      0      0      A
10    954    245     36     82      A
11    196    758    102    194      c
Type: Heterodimer
Binding TFs: P31271 (Homeobox domain, Hox protein A13 N terminal)
HOXA13 (Homeobox domain, Hox protein A13 N terminal)
P31271
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Knosp W. M., Saneyoshi C., Shou S., Bachinger H. P., Stadler H. S. Elucidation, quantitative refinement, and in vivo utilization of the HOXA13 DNA binding site.. J. Biol. Chem. 282:6843-6853 (2007). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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