Transcription Factor

Accessions: 1akh_B (3D-footprint 20231221), 1yrn_B (3D-footprint 20231221)
Names: Alpha-2 repressor, MATalpha2 protein, MATING-TYPE PROTEIN ALPHA-2, Mating-type protein ALPHA2, MTAL2_YEAST, MAT ALPHA2 HOMEODOMAIN
Organisms: Saccharomyces cerevisiae, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P0CY08
Length: 78
Pfam Domains: 8-61 Homeobox domain
20-58 Homeobox KN domain
Sequence:
(in bold interface residues)
1 TKPYRGHRFTKENVRILESWFAKNIENPYLDTKGLENLMKNTSLSRIQIKNWVSNRRRKE 60
61 KTITIAPELADLLSGEPL
Interface Residues: 5, 7, 8, 47, 48, 50, 51, 54, 55, 58, 59, 61, 62
3D-footprint Homologues: 2lkx_A, 1mnm_C, 1k61_B, 1le8_B, 4j19_B, 2ld5_A, 5jlw_D, 1ig7_A, 2xsd_C, 7q3o_C, 1e3o_C, 7xrc_C, 3d1n_M, 2hdd_A, 4xrs_G, 1nk2_P, 1b72_A, 8g87_X, 6es3_K, 3rkq_B, 7psx_B, 5flv_I, 3a01_E, 1puf_B, 1du0_A, 6fqp_B, 3cmy_A, 1zq3_P, 6fqq_E, 4xrm_B, 5zjt_E, 2hos_A, 6m3d_C
Binding Motifs: 1akh_AB TGAnAnAnnnTTTTACA
1yrn_AB TGTAawTnnTtnCnTCA
1yrn_B aTTTACA
Binding Sites: 1akh_C
1akh_D
1yrn_C
1yrn_D
Publications: Li T, Jin Y, Vershon A.K, Wolberger C. Crystal structure of the MATa1/MATalpha2 homeodomain heterodimer in complex with DNA containing an A-tract. Nucleic acids research 26:5707-18 (1998). [Pubmed]

Li T, Stark M.R, Johnson A.D, Wolberger C. Crystal structure of the MATa1/MAT alpha 2 homeodomain heterodimer bound to DNA. Science (New York, N.Y.) 270:262-9 (1995). [Pubmed]
Related annotations: PaperBLAST

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