Transcription Factor

						

			
Accessions: T150741_1.02 (CISBP 1.02), UP00337A (UniPROBE 20160601), P13393 (JASPAR 2024)

			
Names: SPT15, T150741_1.02;, BTF1, TATA sequence-binding protein, TATA-binding factor, TATA-box factor, TATA-box-binding protein, TBP, TBP1, Transcription factor D, Transcription initiation factor TFIID TBP subunit, YER148W, TBP_YEAST
Organisms: Saccharomyces cerevisiae
Libraries: CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]

2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]

3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Description: TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
Notes: experiment type:PBM, family:TBP
Length: 240
Pfam Domains:    65-147 Transcription factor TFIID (or TATA-binding protein, TBP)
  152-237 Transcription factor TFIID (or TATA-binding protein, TBP)
Sequence: 
(in bold interface residues)		   1 MADEERLKEFKEANKIVFDPNTRQVWENQNRDGTKPATTFQSEEDIKRAAPESEKDTSAT   60
  61 SGIVPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGK  120
 121 MVVTGAKSEDDSKLASRKYARIIQKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHG  180
 181 TFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEIYQAFEAIYPVLSEFRKM  240
Interface Residues: 69, 71, 99, 100, 114, 116, 122, 124, 158, 159, 161, 190, 191, 205, 207, 213, 215
3D-footprint Homologues: 6cnb_R, 1cdw_A, 5iy6_P, 7z7n_D, 1qna_B, 5n9g_G, 1ytb_A, 5oqj_O, 1ais_A, 4wzs_D
Binding Motifs: MA0386.1 vwhtaGrwATATATAtwsrwk
UP00337A_1 vwhtaGrwATATATAtwsrwd
M1642_1.02 wwwwtAw
MA0386.2 GrwATATATAt
Binding Sites: AAATATAT
AATATATA
AATATATT
ATATATAA
ATATATAC
ATATATAG
ATATATAT
ATATATTA
ATATATTG
ATTATAAA
ATTATATA
ATTTAAAT
CATATATA
GATATATA
TATATAAA
TATATATA
TATTTAAA
TTATAAAA
TTATATAA
TTTATAAA
			
Publications: *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed]


Newburger D.E, Bulyk M.L. UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. Nucleic acids research 37:D77-82 (2009). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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