Transcription Factor
| Accessions: | HOXC8 (HT-SELEX2 May2017), P31273 (JASPAR 2024) |
| Names: | ENSG00000037965, HOXC8, Homeobox protein Hox-3A, Homeobox protein Hox-C8, HXC8_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P31273 |
| Notes: | TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 242 |
| Pfam Domains: | 150-206 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MSSYFVNPLFSKYKAGESLEPAYYDCRFPQSVGRSHALVYGPGGSAPGFQHASHHVQDFF 60 61 HHGTSGISNSGYQQNPCSLSCHGDASKFYGYEALPRQSLYGAQQEASVVQYPDCKSSANT 120 121 NSSEGQGHLNQNSSPSLMFPWMRPHAPGRRSGRQTYSRYQTLELEKEFLFNPYLTRKRRI 180 181 EVSHALGLTERQVKIWFQNRRMKWKKENNKDKLPGARDEEKVEEEGNEEEEKEEEEKEEN 240 241 KD |
| Interface Residues: | 130, 149, 150, 151, 152, 153, 154, 191, 192, 194, 195, 198, 199, 202, 203, 206, 216, 219 |
| 3D-footprint Homologues: | 1e3o_C, 5zfz_A, 3cmy_A, 1fjl_B, 1puf_A, 1ig7_A, 6a8r_A, 3d1n_M, 1nk2_P, 1zq3_P, 2lkx_A, 2ld5_A, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 1jgg_B, 6es3_K, 4xrs_G, 2hos_A, 4cyc_A, 6m3d_C, 5flv_I, 5zjt_E, 3a01_E, 2h1k_B, 7psx_B, 1b72_A, 5hod_A, 3lnq_A, 7xrc_C, 2xsd_C, 1le8_A, 4xrm_B, 1mnm_C, 1du0_A, 1k61_B, 3l1p_A, 1o4x_A, 8g87_X, 4qtr_D |
| Binding Motifs: | HOXC8_3 / MA1505.1 gyAATTRc HOXC8_methyl_1 rtCrTTAw HOXC8_methyl_2 gyaATtrc MA1505.2 yAATTR |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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