Transcription Factor
| Accessions: | Q6P9G9 (JASPAR 2024) |
| Names: | Zinc finger and SCAN domain-containing protein 19, Zinc finger protein 449, ZN449_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q6P9G9 |
| Length: | 518 |
| Pfam Domains: | 25-119 SCAN domain 313-333 Zinc-finger double domain 322-343 C2H2-type zinc finger 323-345 C2H2-type zinc finger 323-345 Zinc finger, C2H2 type 339-361 Zinc-finger double domain 350-373 C2H2-type zinc finger 351-373 C2H2-type zinc finger 351-373 Zinc finger, C2H2 type 365-390 Zinc-finger double domain 378-402 C2H2-type zinc finger 379-401 C2H2-type zinc finger 379-401 Zinc finger, C2H2 type 397-416 Zinc-finger double domain 406-429 C2H2-type zinc finger 407-429 C2H2-type zinc finger 407-429 Zinc finger, C2H2 type 421-446 Zinc-finger double domain 434-457 C2H2-type zinc finger 435-457 C2H2-type zinc finger 435-457 Zinc finger, C2H2 type 449-473 Zinc-finger double domain 463-485 Zinc finger, C2H2 type 463-477 C2H2-type zinc finger 463-485 C2H2-type zinc finger 477-501 Zinc-finger double domain 490-510 C2H2-type zinc finger 491-513 C2H2-type zinc finger 491-513 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MAVALGCAIQASLNQGSVFQEYDTDCEVFRQRFRQFQYREAAGPHEAFNKLWELCCQWLK 60 61 PKMRSKEQILELLVLEQFLTILPTEIETWVREHCPENRERVVSLIEDLQRELEIPEQQVD 120 121 MHDMLLEELAPVGTAHIPPTMHLESPALQVMGPAQEAPVAEAWIPQAGPPELNYGATGEC 180 181 QNFLDPGYPLPKLDMNFSLENREEPWVKELQDSKEMKQLLDSKIGFEIGIENEEDTSKQK 240 241 KMETMYPFIVTLEGNALQGPILQKDYVQLENQWETPPEDLQTDLAKLVDQQNPTLGETPE 300 301 NSNLEEPLNPKPHKKKSPGEKPHRCPQCGKCFARKSQLTGHQRIHSGEEPHKCPECGKRF 360 361 LRSSDLYRHQRLHTGERPYECTVCKKRFTRRSHLIGHQRTHSEEETYKCLECGKSFCHGS 420 421 SLKRHLKTHTGEKPHRCHNCGKSFSRLTALTLHQRTHTEERPFKCNYCGKSFRQRPSLVI 480 481 HLRIHTGEKPYKCTHCSKSFRQRAGLIMHQVTHFRGLI |
| Interface Residues: | 292, 293, 294, 296, 300, 302, 306, 333, 334, 335, 336, 337, 339, 340, 342, 343, 344, 346, 361, 362, 363, 364, 365, 367, 368, 372, 389, 390, 391, 392, 393, 396, 400, 405, 407, 408, 417, 418, 419, 420, 421, 423, 424, 428, 445, 446, 447, 448, 449, 452, 458, 472, 473, 474, 475, 476, 477, 480, 481, 483, 484, 501, 502, 503, 504, 505, 506, 507, 508, 509 |
| 3D-footprint Homologues: | 4aik_A, 7w1m_H, 8ssu_A, 5v3j_F, 1mey_C, 6blw_A, 5kkq_D, 5ei9_F, 2kmk_A, 2gli_A, 8ssq_A, 2i13_A, 1llm_D, 7ysf_A, 2jpa_A, 7n5w_A, 2wbs_A, 6ml4_A, 4x9j_A, 8gn3_A, 1f2i_J, 6u9q_A, 5kl3_A, 1tf6_A, 5und_A, 8h9h_G, 7eyi_G, 7y3m_I, 2lt7_A, 1g2f_F, 6wmi_A, 5yj3_D, 5yel_A, 5k5i_A, 1tf3_A, 2drp_D, 6e94_A, 1ubd_C, 7y3l_A, 6jnm_A, 8cuc_F, 6a57_A, 3uk3_C, 5k5l_F, 7txc_E, 4m9v_C |
| Binding Motifs: | MA1656.1 cvaAGCCCAACcas MA1656.2 aAGCCCAACc |
| Binding Sites: | MA1656.1.1 MA1656.1.10 MA1656.1.11 MA1656.1.12 MA1656.1.13 / MA1656.1.3 MA1656.1.14 / MA1656.1.4 MA1656.1.15 / MA1656.1.5 MA1656.1.16 / MA1656.1.6 MA1656.1.17 / MA1656.1.7 MA1656.1.18 MA1656.1.19 / MA1656.1.8 MA1656.1.2 MA1656.1.20 / MA1656.1.9 MA1656.1.3 MA1656.1.2 / MA1656.1.4 MA1656.1.5 MA1656.1.6 MA1656.1.7 MA1656.1.8 MA1656.1.9 MA1656.1.1 MA1656.1.10 MA1656.1.11 MA1656.1.12 MA1656.1.13 MA1656.1.14 MA1656.1.15 MA1656.1.16 MA1656.1.17 MA1656.1.18 MA1656.1.19 MA1656.1.20 MA1656.2.1 MA1656.2.10 / MA1656.2.13 / MA1656.2.16 MA1656.2.11 / MA1656.2.2 MA1656.2.12 MA1656.2.14 MA1656.2.15 MA1656.2.17 / MA1656.2.6 MA1656.2.18 MA1656.2.19 MA1656.2.20 MA1656.2.3 MA1656.2.4 MA1656.2.5 MA1656.2.7 MA1656.2.8 MA1656.2.9 |
| Publications: | Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.