Transcription Factor
| Accessions: | Q6BEB4 (JASPAR 2024) |
| Names: | SP5_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 398 |
| Pfam Domains: | 296-320 C2H2-type zinc finger 296-320 Zinc finger, C2H2 type 312-339 Zinc-finger double domain 326-350 C2H2-type zinc finger 326-350 Zinc finger, C2H2 type 343-365 Zinc-finger double domain 356-378 C2H2-type zinc finger 356-378 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MAAVAVLRNDSLQAFLQDRTPSASPDLGKHSPLALLAATCSRIGQPGAAAPPDFLQVPYD 60 61 PALGSPSRLFHPWTADMPAHSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTPPADPS 120 121 YPYEFSPVKMLPSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQLSP 180 181 NPAPDDLPWWSIPQAGAGPGASGVPGSGLSGACAGAPHAPRFPASAAAAAAAAAALQRGL 240 241 VLGPSDFAQYQSQIAALLQTKAPLAATARRCRRCRCPNCQAAGGAPEAEPGKKKQHVCHV 300 301 PGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACPE 360 361 CGKRFMRSDHLAKHVKTHQNKKLKVAEAGVKREDARDL |
| Interface Residues: | 269, 282, 284, 287, 290, 294, 308, 309, 310, 311, 312, 314, 315, 317, 318, 321, 338, 339, 340, 341, 342, 344, 345, 346, 349, 366, 367, 368, 369, 370, 371, 372, 373, 374, 377, 389, 393 |
| 3D-footprint Homologues: | 2han_B, 4umm_E, 7eyi_G, 5kkq_D, 6jnm_A, 8cuc_F, 7y3l_A, 6ml4_A, 1tf3_A, 7n5w_A, 3uk3_C, 1g2f_F, 6u9q_A, 5yel_A, 5ei9_F, 2kmk_A, 1tf6_A, 5kl3_A, 6wmi_A, 5k5i_A, 8ssq_A, 1ubd_C, 7w1m_H, 5und_A, 2i13_A, 1mey_C, 5k5l_F, 8ssu_A, 4x9j_A, 6blw_A, 2gli_A, 8h9h_G, 5v3j_F, 6e94_A, 7ysf_A, 2lt7_A, 7y3m_I, 6a57_A, 2jpa_A, 7txc_E, 1llm_D, 2wbs_A, 2drp_D, 1f2i_J, 4m9v_C, 8gn3_A, 5yj3_D |
| Binding Motifs: | MA1965.1 cyCCTCCCcs MA1965.2 CCTCCC |
| Binding Sites: | MA1965.2.7 MA1965.1.1 / MA1965.1.11 / MA1965.1.12 / MA1965.1.17 / MA1965.1.19 MA1965.1.10 / MA1965.1.9 MA1965.1.10 / MA1965.1.11 MA1965.1.13 / MA1965.1.14 MA1965.1.14 / MA1965.1.16 MA1965.1.15 / MA1965.1.17 MA1965.1.16 / MA1965.1.18 MA1965.1.18 / MA1965.1.19 / MA1965.1.20 MA1965.1.2 MA1965.1.20 MA1965.1.3 MA1965.1.4 MA1965.1.5 MA1965.1.6 MA1965.1.7 MA1965.1.7 / MA1965.1.8 MA1965.1.8 / MA1965.1.9 MA1965.1.12 MA1965.1.13 MA1965.1.15 MA1965.2.1 / MA1965.2.10 / MA1965.2.11 / MA1965.2.12 / MA1965.2.13 / MA1965.2.14 / MA1965.2.15 / MA1965.2.16 / MA1965.2.17 / MA1965.2.18 / MA1965.2.19 / MA1965.2.2 / MA1965.2.20 / MA1965.2.3 / MA1965.2.4 / MA1965.2.5 / MA1965.2.6 / MA1965.2.8 / MA1965.2.9 |
| Publications: | Huggins IJ, Bos T, Gaylord O, Jessen C, Lonquich B, Puranen A, Richter J, Rossdam C, Brafman D, Gaasterland T, Willert K. The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells. Nat Commun 8:1034 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.