Transcription Factor

						

			
Accessions: 1mhd_A (3D-footprint 20231221), 1mhd_B (3D-footprint 20231221)

			
Names: hMAD-3, hSMAD3, JV15-2, MAD homolog 3, Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, SMAD 3, SMAD family member 3, SMAD3_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P84022
Length: 123
Pfam Domains:    22-122 MH1 domain
Sequence: 
(in bold interface residues)		   1 PIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPR   60
  61 SLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQR  120
 121 VET
Interface Residues: 22, 24, 28, 63, 65, 67, 70, 72
3D-footprint Homologues: 8cli_A, 6fzs_A, 6h3r_A, 5nm9_A, 5od6_A, 5mey_A, 2qnf_A
Binding Motifs: 1mhd_AB TGTCTATACT
1mhd_B TAGACT
Binding Sites: 1mhd_C
1mhd_D
			
Publications: Shi Y., Wang Y. F., Jayaraman L., Yang H., Massague J., Pavletich N. P. Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell 94:585-594 (1998). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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