Transcription Factor
Accessions: | DLX3_Full (HumanTF2 1.0) |
Names: | DLX3, DLX3_HUMAN |
Organisms: | Homo sapiens |
Libraries: | HumanTF2 1.0 1 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
Uniprot: | O60479 |
Notes: | Ensembl ID: ENSG00000064195; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: Homeodomain; Clone source: Jolma et al. 2013 |
Length: | 288 |
Pfam Domains: | 27-106 Homeobox protein distal-less-like N terminal 130-186 Homeobox domain |
Sequence: (in bold interface residues) | 1 MSGSFDRKLSSILTDISSSLSCHAGSKDSPTLPESSVTDLGYYSAPQHDYYSGQPYGQTV 60 61 NPYTYHHQFNLNGLAGTGAYSPKSEYTYGASYRQYGAYREQPLPAQDPVSVKEEPEAEVR 120 121 MVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNR 180 181 RSKFKKLYKNGEVPLEHSPNNSDSMACNSPPSPALWDTSSHSTPAPARSQLPPPLPYSAS 240 241 PSYLDDPTNSWYHAQNLSGPHLQQQPPQPATLHHASPGPPPNPGAVY* |
Interface Residues: | 28, 30, 130, 131, 132, 133, 171, 172, 174, 175, 178, 179, 182, 183, 186 |
3D-footprint Homologues: | 8a1c_A, 1fjl_B, 5zjt_E, 2h1k_B, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 1mnm_C, 3d1n_M, 5zfz_A, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 7q3o_C, 6es3_K, 2ld5_A, 4j19_B, 3a01_E, 7psx_B, 1b72_A, 5hod_A, 3lnq_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1jgg_B, 4xrs_G, 2hos_A, 4cyc_A, 1au7_A, 5flv_I, 1le8_A, 7xrc_C, 1e3o_C, 2xsd_C, 1o4x_A, 8g87_X, 4qtr_D, 1du0_A, 1puf_B, 1k61_B, 3l1p_A |
Binding Motifs: | ERF_DLX3_1 avmGGAwryrgsyamTtr ERF_DLX3_2 rccGGAwrkvsyaaTta ETV2_DLX3_1 rcCGGAAryrrsskTAATtr ETV2_DLX3_2 acCGGAAryrvsvyaATtr ETV2_DLX3_2_3 rcCGGAAryrrgyaATTa ETV2_DLX3_2_3_4 TAATkrswacCGGAWryr GCM2_DLX3_1 aTrcGGGywkwyttAATtr GCM2_DLX3_2 aTrcGGGywrkdtAAttr MEIS1_DLX3 TGACAgsyTAATtr MGA_DLX3_1 AGGTGwTAATtr MGA_DLX3_2 yvATTAarGGTGtGAr TEAD4_DLX3_1 rCATwCCrhsyaATTA TEAD4_DLX3_2 rCATwCytyssTAATtr TEAD4_DLX3_2_3 rCATwCCdysstAAtkr TEAD4_DLX3_2_3_4 rCATwCCrmsyaATTA TFAP2C_DLX3_1 yssCysvrGGCaygggssTAATkr TFAP2C_DLX3_2 gsCCysrRGscaygskrTAATkr TFAP2C_DLX3_2_3 msCCybmrGsCaygcsymATTA TFAP4_DLX3_1 kCAGsTGdvggrsgyaATkr TFAP4_DLX3_2 yCAGsTGkdbgkrsgtaATtr TFAP4_DLX3_2_3 AwCAGCTGATywTAATtr TFAP4_DLX3_2_3_4 AwCAGCTGwTysssgYaatkr |
Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.