Transcription Factor

Accessions: DLX3_Full (HumanTF2 1.0)
Names: DLX3, DLX3_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: O60479
Notes: Ensembl ID: ENSG00000064195; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: Homeodomain; Clone source: Jolma et al. 2013
Length: 288
Pfam Domains: 27-106 Homeobox protein distal-less-like N terminal
130-186 Homeobox domain
Sequence:
(in bold interface residues)
1 MSGSFDRKLSSILTDISSSLSCHAGSKDSPTLPESSVTDLGYYSAPQHDYYSGQPYGQTV 60
61 NPYTYHHQFNLNGLAGTGAYSPKSEYTYGASYRQYGAYREQPLPAQDPVSVKEEPEAEVR 120
121 MVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNR 180
181 RSKFKKLYKNGEVPLEHSPNNSDSMACNSPPSPALWDTSSHSTPAPARSQLPPPLPYSAS 240
241 PSYLDDPTNSWYHAQNLSGPHLQQQPPQPATLHHASPGPPPNPGAVY*
Interface Residues: 28, 30, 130, 131, 132, 133, 171, 172, 174, 175, 178, 179, 182, 183, 186
3D-footprint Homologues: 8a1c_A, 1fjl_B, 5zjt_E, 2h1k_B, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 1mnm_C, 3d1n_M, 5zfz_A, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 7q3o_C, 6es3_K, 2ld5_A, 4j19_B, 3a01_E, 7psx_B, 1b72_A, 5hod_A, 3lnq_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1jgg_B, 4xrs_G, 2hos_A, 4cyc_A, 1au7_A, 5flv_I, 1le8_A, 7xrc_C, 1e3o_C, 2xsd_C, 1o4x_A, 8g87_X, 4qtr_D, 1du0_A, 1puf_B, 1k61_B, 3l1p_A
Binding Motifs: ERF_DLX3_1 avmGGAwryrgsyamTtr
ERF_DLX3_2 rccGGAwrkvsyaaTta
ETV2_DLX3_1 rcCGGAAryrrsskTAATtr
ETV2_DLX3_2 acCGGAAryrvsvyaATtr
ETV2_DLX3_2_3 rcCGGAAryrrgyaATTa
ETV2_DLX3_2_3_4 TAATkrswacCGGAWryr
GCM2_DLX3_1 aTrcGGGywkwyttAATtr
GCM2_DLX3_2 aTrcGGGywrkdtAAttr
MEIS1_DLX3 TGACAgsyTAATtr
MGA_DLX3_1 AGGTGwTAATtr
MGA_DLX3_2 yvATTAarGGTGtGAr
TEAD4_DLX3_1 rCATwCCrhsyaATTA
TEAD4_DLX3_2 rCATwCytyssTAATtr
TEAD4_DLX3_2_3 rCATwCCdysstAAtkr
TEAD4_DLX3_2_3_4 rCATwCCrmsyaATTA
TFAP2C_DLX3_1 yssCysvrGGCaygggssTAATkr
TFAP2C_DLX3_2 gsCCysrRGscaygskrTAATkr
TFAP2C_DLX3_2_3 msCCybmrGsCaygcsymATTA
TFAP4_DLX3_1 kCAGsTGdvggrsgyaATkr
TFAP4_DLX3_2 yCAGsTGkdbgkrsgtaATtr
TFAP4_DLX3_2_3 AwCAGCTGATywTAATtr
TFAP4_DLX3_2_3_4 AwCAGCTGwTysssgYaatkr
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

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