Transcription Factor

Accessions: FOSB (HT-SELEX2 May2017)
Names: ENSG00000125740, FOSB
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2
Length: 143
Pfam Domains: 57-115 bZIP transcription factor
59-111 Basic region leucine zipper
Sequence:
(in bold interface residues)
1 YDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLTPEEEE 60
61 KRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLV 120
121 AHKPGCKIPYEEGPGPGPLAEVR
Interface Residues: 65, 66, 69, 70, 72, 73, 76, 77, 80
3D-footprint Homologues: 7x5e_E, 5vpe_C, 7x5e_F, 2wt7_A, 6mg1_B, 1nwq_C, 1skn_P, 5t01_B, 5vpe_D
Binding Motifs: FOSB_2 grTGACGTCAyc
FOSB_methyl_1 gATGAyGTCATc
Related annotations: PaperBLAST

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