Transcription Factor
| Accessions: | PPARG_MOUSE (HOCOMOCO 10), P37238 (JASPAR 2024) |
| Names: | Nuclear receptor subfamily 1 group C member 3, Peroxisome proliferator-activated receptor gamma, PPAR-gamma, PPARG_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P37238 |
| Length: | 505 |
| Pfam Domains: | 31-108 PPAR gamma N-terminal region 138-204 Zinc finger, C4 type (two domains) 321-484 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSF 60 61 DIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKT 120 121 QLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC 180 181 RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR 240 241 ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE 300 301 QSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLAS 360 361 LMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII 420 421 LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQL 480 481 LHVIKKTETDMSLHPLLQEIYKDLY |
| Interface Residues: | 147, 148, 150, 151, 157, 158, 160, 161, 164, 165, 188, 210, 212, 214, 218, 220 |
| 3D-footprint Homologues: | 6fbq_A, 6l6q_B, 7wnh_D, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B |
| Binding Motifs: | MA0065.2 strGGgcArAGGkcA PPARG_MOUSE.H10MO.A|M01303 awstrGGkcArAGGkcA MA0065.3 rGGgcArAGGkcA |
| Binding Sites: | MA0065.2.1 MA0065.2.10 MA0065.2.11 MA0065.2.12 MA0065.2.13 MA0065.2.14 MA0065.2.15 MA0065.2.16 MA0065.2.17 MA0065.2.18 MA0065.2.19 MA0065.2.2 MA0065.2.20 MA0065.2.3 MA0065.2.4 MA0065.2.5 MA0065.2.6 MA0065.2.7 MA0065.2.8 MA0065.2.9 |
| Publications: | Nielsen R, Pedersen T.A, Hagenbeek D, Moulos P, Siersbaek R, Megens E, Denissov S, Børgesen M, Francoijs K.J, Mandrup S, Stunnenberg H.G. Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis. Genes & development 22:2953-67 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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