Transcription Factor
| Accessions: | UP00615D (UniPROBE 20160601) |
| Names: | ALL1-responsive protein ARP1, Brx1, Homeobox protein PITX2, IDG2, IGDS, IGDS2, IHG2, IRID2, MGC111022, MGC20144, Otlx2, Paired-like homeodomain transcription factor 2, pituitary homeobox 2, PITX2_R130W, PTX2, RGS, RIEG, RIEG bicoid-related homeobox transcription factor, RIEG1, RS, Solurshin |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | pituitary homeobox 2: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activ |
| Length: | 86 |
| Pfam Domains: | 15-71 Homeobox domain |
| Sequence: (in bold interface residues) | 1 EDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVWV 60 61 WFKNRRAKWRKRERNQQAELCKNGFG |
| Interface Residues: | 15, 16, 17, 18, 20, 56, 57, 59, 60, 63, 64, 67, 68, 71, 72 |
| 3D-footprint Homologues: | 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 5zfz_A, 1ig7_A, 2h1k_B, 1jgg_B, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 4j19_B, 3lnq_A, 1mnm_C, 2ld5_A, 7psx_B, 3rkq_B, 1puf_B, 6es3_K, 1b72_A, 4xrs_G, 2hdd_A, 7q3o_C, 2r5y_A, 5flv_I, 3l1p_A, 2hos_A, 5zjt_E, 3a01_E, 5hod_A, 5jlw_D, 2h8r_B, 1ic8_B, 1le8_A, 1e3o_C, 4qtr_D, 1k61_B, 4cyc_A, 1du0_A, 1o4x_A, 8g87_X, 1le8_B, 6wig_A |
| Binding Motifs: | UP00615D_1 twyktwwmsTAATTAykmmcawa |
| Binding Sites: | AATTAATA AATTAATT ACTAATTA AGTAATTA ATATATTA ATATTATG CTAATTAG GTAATTAC TTAATTAA AAAAATAT AAAGTATA AAATATGT AATATGTA AATTATCA ACATACAT ATACATAT ATTACAAG CATATTAA GTGTATTA TGAATTCA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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