Transcription Factor

						

			
Accessions: 6b0r_D (3D-footprint 20241219)

			
Names: Wilms tumor protein, WT1_HUMAN, WT33
Organisms: Homo sapiens
Libraries: 3D-footprint 20241219 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 117
Pfam Domains:      6-28 C2H2-type zinc finger
    20-47 Zinc-finger double domain
    34-58 C2H2-type zinc finger
    34-58 Zinc finger, C2H2 type
    51-75 Zinc-finger double domain
    64-86 C2H2-type zinc finger
    64-86 Zinc finger, C2H2 type
   78-104 Zinc-finger double domain
   92-114 C2H2-type zinc finger
   92-116 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 MRPFMCAYPGCNKRYFKLSHLQRHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTG   60
  61 VKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQ
Interface Residues: 16, 17, 18, 19, 20, 22, 23, 25, 26, 29, 46, 47, 48, 49, 50, 52, 53, 57, 74, 75, 76, 77, 78, 80, 81, 104, 105, 106, 107, 108, 110, 111
3D-footprint Homologues: 7n5w_A, 8ssq_A, 7w1m_H, 2kmk_A, 6u9q_A, 8ssu_A, 5v3j_F, 2gli_A, 8h9h_G, 7ysf_A, 6e94_A, 2lt7_A, 1tf6_A, 2jpa_A, 1ubd_C, 8cuc_F, 7y3l_A, 1tf3_A, 2drp_D, 7txc_E, 7y3m_I, 8gn3_A
Binding Motifs: 6b0r_D GCGTGGGAGGGtt
Binding Sites: 6b0r_E
6b0r_F
			
Publications: Wang D, Horton JR, Zheng Y, Blumenthal RM, Zhang X, Cheng X. Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites. Nucleic Acids Res 46:3864-3877 (2018). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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