Transcription Factor
| Accessions: | T120865_1.02 (CISBP 1.02), UP00355A (UniPROBE 20160601), P22035 (JASPAR 2024) |
| Names: | BAS1, T120865_1.02;, Myb-like DNA-binding protein BAS1, YKR099W, BAS1_YEAST |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes |
| Notes: | experiment type:PBM, family:Myb/SANT |
| Length: | 811 |
| Pfam Domains: | 42-127 Myb-like DNA-binding domain 116-159 Myb-like DNA-binding domain 119-163 Myb-like DNA-binding domain 171-212 Myb-like DNA-binding domain 172-213 Myb-like DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MSNISTKDIRKSKPKRGSGFDLLEVTESLGYQTHRKNGRNSWSKDDDNMLRSLVNESAKE 60 61 LGYENGLEDVKTIQQSNHLSKCIAWDVLATRFKHTVRTSKDVRKRWTGSLDPNLKKGKWT 120 121 QEEDEQLLKAYEEHGPHWLSISMDIPGRTEDQCAKRYIEVLGPGSKGRLREWTLEEDLNL 180 181 ISKVKAYGTKWRKISSEMEFRPSLTCRNRWRKIITMVVRGQASEVITKAIKENKNIDMTD 240 241 GKLRQHPIADSDIRSDSTPNKEEQLQLSQQNNPSLIKQDILNVKENESSKLPRLKDNDGP 300 301 ILNDSKPQALPPLKEISAPPPIRMTQVGQTHTSGSIRSKVSLPIEGLSQMNKQSPGGISD 360 361 SPQTSLPPAFNPASLDEHMMNSNSISDSPKHAYSTVKTREPNSSSTQWKFTLKDGQGLSI 420 421 SNGTIDSTKLVKELVDQAKKYSLKISIHQHIHNHYVTSTDHPVSSNTGLSNIGNINGNPL 480 481 LMDSFPHMGRQLGNGLPGLNSNSDTFNPEYRTSLDNMDSDFLSRTPNYNAFSLEATSHNP 540 541 ADNANELGSQSNRETNSPSVFYPQANTLIPTNSTATNNEIIQGNVSANSMSPNFNGTNGK 600 601 APSSTASYTTSGSEMPPDVGPNRIAHFNYLPPTIRPHLGSSDATRGADLNKLLNPSPNSV 660 661 RSNGSKTKKKEKRKSESSQHHSSSSVTTNKFNHIDQSEISRTTSRSDTPLRDEDGLDFWE 720 721 TLRSLATTNPNPPVEKSAENDGAKPQVVHQGIGSHTEDSSLGSHSGGYDFFNELLDKKAD 780 781 TLHNEAKKTSEHDMTSGGSTDNGSVLPLNPS |
| Interface Residues: | 100, 103, 104, 108, 116, 149, 150, 151, 152, 154, 155, 158, 159, 160, 203, 204, 207, 208, 211, 522, 553, 555, 558, 559, 560, 561, 562 |
| 3D-footprint Homologues: | 3zqc_A, 6kks_A, 7xur_A, 3osg_A, 2kdz_A, 1mse_C, 5eyb_B, 1w0t_A, 8fcj_E |
| Binding Motifs: | MA0278.1 kcwyrgCCvGAGTCArdwyra UP00355A_1 kcwyrrCCvGAGTCArdwyra M1375_1.02 MmGAGTCA MA0278.2 rgCCvGAGTCAr |
| Binding Sites: | ACGAGTCA AGAGTCAA AGAGTCAC AGGAGTCA CAGAGTCA CCAGAGTC CCCGAGTC CCGAGTCA CGAGTCAA CGAGTCAG CGGAGTCA CTGACTCC GACTCCTC GAGTCAAA GGAGTCAC ACAGAGTC ACTGACTC AGACTCTG CGAGTCAC GACTCTGC |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] Newburger D.E, Bulyk M.L. UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. Nucleic acids research 37:D77-82 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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