Transcription Factor

						

			
Accessions: 3fhz_A (3D-footprint 20231221), 3fhz_E (3D-footprint 20231221), 3fhz_F (3D-footprint 20231221), 3laj_D (3D-footprint 20231221), 3laj_F (3D-footprint 20231221)

			
Names: Arginine repressor, ARGR_MYCTU
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P9WPY8
Length: 155
Pfam Domains:      1-70 Arginine repressor, DNA binding domain
   86-153 Arginine repressor, C-terminal domain
Sequence: 
(in bold interface residues)		   1 ANRAGRQARIVAILSSAQVRSQNELAALLAAEGIEVTQATLSRDLEELGAVKLRGADGGT   60
  61 GIYVVPEDGSPVRGVSGGTDRMARLLGELLVSTDDSGNLAVLRTPPGAAHYLASAIDRAA  120
 121 LPQVVGTIAGDDTILVVAREPTTGAQLAGMFENLR
Interface Residues: 37, 38, 39, 40, 42, 43
3D-footprint Homologues: 2p5l_D, 3lap_B, 4u7b_B
Binding Motifs: 3laj_BF TGCATAnnGATGC
3fhz_AD TGCATAnngATTMA
3fhz_BF TGAATcnnTAyTCA
3fhz_CE TGAaTAnngATGCA
3fhz_E gATgCA
3laj_AD GCATCnnTATGCA
Binding Sites: 3laj_I / 3laj_K
3laj_J / 3laj_L
3fhz_I / 3fhz_K
3fhz_J / 3fhz_L
			
Publications: Cherney L.T, Cherney M.M, Garen C.R, James M.N. The structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and Co-repressor, L-arginine. Journal of molecular biology 388:85-97 (2009). [Pubmed]


Cherney L.T, Cherney M.M, Garen C.R, James M.N. Crystal structure of the intermediate complex of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator reveals detailed mechanism of arginine repression. Journal of molecular biology 399:240-54 (2010). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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