Transcription Factor

						

			
Accessions: 6n62_F (3D-footprint 20231221)

			
Names: Q0P6L9_ECOLX, RNA polymerase sigma factor RpoD, Sigma-70
Organisms: Escherichia coli
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q0P6L9
Length: 471
Pfam Domains:      2-33 Sigma-70 factor, region 1.2
    44-74 Sigma-70, non-essential region
   75-206 Sigma-70, non-essential region
  237-307 Sigma-70 region 2 
  316-392 Sigma-70 region 3
  405-458 Sigma-70, region 4
Sequence: 
(in bold interface residues)		   1 TTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEAITYLLEQYNRVEA   60
  61 EEARLSDLITGFVDIDPELAREKFAELRAQYVVTRDTIKHATAQEEILKLSEVFKQFRLV  120
 121 PKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKMPKKNFITLFTGNETSDTWFNAAIAM  180
 181 NKPWSEKLHDVSEEVHRALQKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEA  240
 241 NLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRS  300
 301 IADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPEDKIRKVLKIAK  360
 361 EPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAATHDVLAGLTAREAKVLRMR  420
 421 FGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSEVLRSFLDD
Interface Residues: 110, 120, 122, 123, 125, 126, 431, 432, 441, 442, 443, 444, 446, 447
3D-footprint Homologues: 3h0d_A, 3n97_A, 6ido_B, 8cyf_B
Binding Motifs: 6n62_F AAac
Binding Sites: 6n62_N
6n62_T
			
Publications: Braffman NR, Piscotta FJ, Hauver J, Campbell EA, Link AJ, Darst SA. Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc Natl Acad Sci U S A 116:1273-1278 (2019). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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